Literature DB >> 30633927

GATA6: a new predictor for prognosis in ovarian cancer.

Weiwei Shen1, Na Niu2, Barrett Lawson2, Lisha Qi3, Jing Zhang4, Ting Li5, Helong Zhang6, Jinsong Liu7.   

Abstract

Ovarian cancer (OC) is the main cause of gynecological cancer-associated mortality. Improving the diagnosis is important for guiding clinical treatment. The present study aimed to investigate the relationship between expression of GATA6, a stem cell factor, and its prognosis in OC. In total, 521 OC cases were included. Immunohistochemistry analysis demonstrated that GATA6 was expressed in both high-grade serous carcinoma as well as non-serous tumors. High grade serous carcinoma showed a higher percentage of GATA6 positive staining. Positive staining of GATA6 showed worse overall survival (OS) in all ovarian cancers or serous and non-serous carcinoma individually. GATA6 was revealed as an independent risk factor for prognosis by multivariate Cox analysis. In all, GATA6 may present as a novel marker for poor prognosis in OC.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GATA6; Ovarian cancer; Prognosis; Stem cell and lineage differentiation factor

Mesh：

Substances：

Year:  2019        PMID： 30633927     DOI： 10.1016/j.humpath.2019.01.001

Source DB:  PubMed          Journal:  Hum Pathol        ISSN： 0046-8177            Impact factor:   3.466


  7 in total

1.  Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients.

Authors:  Feiling Feng; Xiaobing Wu; Xiaoliang Shi; Qingxiang Gao; Yue Wu; Yong Yu; Qingbao Cheng; Bin Li; Bin Yi; Chen Liu; Qing Hao; Lin Zhang; Chunfang Gao; Xiaoqing Jiang
Journal:  Int J Clin Oncol       Date:  2021-01-02       Impact factor: 3.402

2.  LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca2+ concentration via transcription factor GATA6.

Authors:  Haiqing He; Shuiqing Wu; Kai Ai; Ran Xu; Zhaohui Zhong; Yinhuai Wang; Lei Zhang; Xiaokun Zhao; Xuan Zhu
Journal:  Cell Oncol (Dordr)       Date:  2020-10-01       Impact factor: 6.730

3.  Expression of B7-H4 and IDO1 is associated with drug resistance and poor prognosis in high-grade serous ovarian carcinomas.

Authors:  Na Niu; Weiwei Shen; Yanping Zhong; Robert C Bast; Amir Jazaeri; Anil K Sood; Jinsong Liu
Journal:  Hum Pathol       Date:  2021-04-19       Impact factor: 3.466

4.  The underlying molecular mechanism and identification of transcription factor markers for laryngeal squamous cell carcinoma.

Authors:  Bin-Yu Mo; Guo-Sheng Li; Su-Ning Huang; Wei-Ying He; Li-Yuan Xie; Zhu-Xin Wei; Ya-Si Su; Yue Liang; Li Yang; Cheng Ye; Wen-Bin Dai; Lin Ruan
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

Review 5.  Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer.

Authors:  Dhananjay Huilgol; Prabhadevi Venkataramani; Saikat Nandi; Sonali Bhattacharjee
Journal:  Genes (Basel)       Date:  2019-10-12       Impact factor: 4.096

6.  GATA6 promotes epithelial-mesenchymal transition and metastasis through MUC1/β-catenin pathway in cholangiocarcinoma.

Authors:  Xiang Deng; Peng Jiang; Jian Chen; Jianwei Li; Dajiang Li; Yu He; Yan Jiang; Yujun Zhang; Shuangnian Xu; Xi Li; Shuguang Wang; Feng Tian
Journal:  Cell Death Dis       Date:  2020-10-15       Impact factor: 8.469

7.  GATA binding protein 6 (GATA6) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy.

Authors:  Patrick Sven Plum; Heike Löser; Thomas Zander; Ahlem Essakly; Christiane J Bruns; Axel M Hillmer; Hakan Alakus; Wolfgang Schröder; Reinhard Büttner; Florian Gebauer; Alexander Quaas
Journal:  J Cancer Res Clin Oncol       Date:  2020-12-10       Impact factor: 4.553
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.