| Literature DB >> 30633655 |
Daniele Campa1, Alessandro Martino2, Angelica Macauda1,2, Marek Dudziński3, Anna Suska4, Agnieszka Druzd-Sitek5, Marc-Steffen Raab6,7, Victor Moreno8, Stefanie Huhn9, Aleksandra Butrym10, Juan Sainz11,12,13, Gergely Szombath14, Marcin Rymko15, Herlander Marques16, Fabienne Lesueur17,18,19,20, Annette Juul Vangsted21, Ulla Vogel22, Marcin Kruszewski23, Edyta Subocz24, Gabriele Buda25, Elżbieta Iskierka-Jażdżewska26, Rafael Ríos11,12,13, Maximilian Merz6, Ben Schöttker27,28, Grzegorz Mazur10, Emeline Perrial29, Joaquin Martinez-Lopez30, Katja Butterbach28, Ramón García Sanz31, Hartmut Goldschmidt6,32, Hermann Brenner27,28,33,34, Krzysztof Jamroziak35, Rui Manuel Reis16,36,37, Katalin Kadar14, Charles Dumontet29, Marzena Wątek38, Eva Kannik Haastrup39, Grzegorz Helbig40, Artur Jurczyszyn4, Andrés Jerez41, Judit Varkonyi14, Torben Barington42, Norbert Grzasko43,44, Jan Maciej Zaucha45, Vibeke Andersen46,47, Daria Zawirska48, Federico Canzian2.
Abstract
Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.Entities:
Keywords: Multiple myeloma; class switch recombination; genetic polymorphisms; overall survival; progression-free survival; susceptibility
Year: 2019 PMID： 30633655 DOI： 10.1080/10428194.2018.1551536
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022