BACKGROUND: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. METHODS: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. RESULTS: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P = .02). CONCLUSION: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.
BACKGROUND: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. METHODS: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. RESULTS: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P = .02). CONCLUSION: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.
Authors: Lucrezia Togni; Vito Carlo Alberto Caponio; Nicoletta Zerman; Giuseppe Troiano; Khrystyna Zhurakivska; Lorenzo Lo Muzio; Andrea Balercia; Marco Mascitti; Andrea Santarelli Journal: Cancers (Basel) Date: 2022-07-22 Impact factor: 6.575
Authors: Amr Elseragy; Ibrahim O Bello; Awais Wahab; Ricardo D Coletta; Antti A Mäkitie; Ilmo Leivo; Alhadi Almangush; Tuula Salo Journal: Head Neck Date: 2022-02-28 Impact factor: 3.821
Authors: Luca Calabrese; Maria Eleonora Bizzoca; Roberto Grigolato; Fausto Antonio Maffini; Marta Tagliabue; Rosa Negro; Stefania Leuci; Michele Davide Mignogna; Lorenzo Lo Muzio Journal: Life (Basel) Date: 2020-09-12
Authors: Tuula Salo; Ilmo Leivo; Alhadi Almangush; Ibrahim O Bello; Ilkka Heikkinen; Jaana Hagström; Caj Haglund; Luiz Paulo Kowalski; Pentti Nieminen; Ricardo D Coletta; Antti A Mäkitie Journal: Virchows Arch Date: 2020-09-21 Impact factor: 4.064