Wenjie Yu1,2, Yu Dou3, Ketao Wang3, Yanguo Liu1,4, Jintang Sun1, Han Gao3, Shaohua Liu3, Fengcai Wei3, Daoying Yuan3, Xiaobin Song3, Xun Qu1,5. 1. Institute of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, China. 2. Department of Oncology, Yantai affiliated Hospital of Binzhou Medicial University, Yantai, Shandong, China. 3. Department of Oral and Maxillofacial Surgery and Institution of Dental Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. 4. Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China. 5. Key Laboratory of Precision Biomedicine, Institute of Zhongyuan Biomedical Sciences, Liaocheng People's hospital, Liaocheng, Shandong, China.
Abstract
BACKGROUND: To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse. METHODS: Clinic-pathologic and hematological records were retrospectively retrieved. Patients completed follow-up period were included for survival and relapse analysis. RESULTS: The preoperative NLR value was a prognostic factor for both overall survival and relapse-free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse. CONCLUSIONS: The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.
BACKGROUND: To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse. METHODS: Clinic-pathologic and hematological records were retrospectively retrieved. Patients completed follow-up period were included for survival and relapse analysis. RESULTS: The preoperative NLR value was a prognostic factor for both overall survival and relapse-free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse. CONCLUSIONS: The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.