Literature DB >> 3063270

DNA polymorphisms of the apolipoprotein genes--their use in the investigation of the genetic component of hyperlipidaemia and atherosclerosis.

S E Humphries1.   

Abstract

DNA probes for all eight of the major apolipoprotein genes are now available. The chromosomal location, the basic structure and in many cases the nucleotide sequences of the normal genes are known. Common DNA polymorphisms of all of the genes have been detected. These have been been used in a number of ways to investigate rare inherited defects of the apolipoprotein genes, to study the potential involvement of different variants of the genes in the development of hyperlipidaemia in patients, and to investigate the contribution of common variation in these genes in the determination of serum lipid levels in the normal population.

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Year:  1988        PMID： 3063270     DOI： 10.1016/0021-9150(88)90069-x

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  19 in total

Review 1.  The Gordon Wilson Lecture. Plasma cholesterol: atherogenesis and mortality.

Authors:  W R Fisher
Journal:  Trans Am Clin Climatol Assoc       Date:  1993

Review 2.  Genetic basis of lipoprotein disorders.

Authors:  J L Breslow
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

Review 3.  Dissecting the genetic contribution to coronary heart disease.

Authors:  J W MacCluer; C M Kammerer
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

4.  Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels.

Authors:  J C Cohen; Z Wang; S M Grundy; M R Stoesz; R Guerra
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808

5.  Genetic studies of human apolipoproteins. VIII. Role of the apolipoprotein H polymorphism in relation to serum lipoprotein concentrations.

Authors:  B Sepehrnia; M I Kamboh; L L Adams-Campbell; C H Bunker; M Nwankwo; P P Majumder; R E Ferrell
Journal:  Hum Genet       Date:  1989-05       Impact factor: 4.132

6.  The human apolipoprotein B 3' hypervariable region: detection of eight new alleles and comparisons of allele frequencies in blacks and whites.

Authors:  J E Hixson; P K Powers; C A McMahan
Journal:  Hum Genet       Date:  1993-06       Impact factor: 4.132

7.  DNA markers associated with high versus low IQ: the IQ Quantitative Trait Loci (QTL) Project.

Authors:  R Plomin; G E McClearn; D L Smith; S Vignetti; M J Chorney; K Chorney; C P Venditti; S Kasarda; L A Thompson; D K Detterman
Journal:  Behav Genet       Date:  1994-03       Impact factor: 2.805

8.  Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels.

Authors:  S S Deeb; R A Failor; B G Brown; J D Brunzell; J J Albers; A G Motulsky; E Wijsman
Journal:  Hum Genet       Date:  1992-02       Impact factor: 4.132

9.  Patterns of association between genetic variability in apolipoprotein (apo) B, apo AI-CIII-AIV, and cholesterol ester transfer protein gene regions and quantitative variation in lipid and lipoprotein traits: influence of gender and exogenous hormones.

Authors:  A Kessling; S Ouellette; O Bouffard; A Chamberland; C Bétard; E Selinger; M Xhignesse; S Lussier-Cacan; J Davignon
Journal:  Am J Hum Genet       Date:  1992-01       Impact factor: 11.025

10.  Polymorphisms of the apolipoprotein and angiotensin converting enzyme genes in young North Karelian patients with coronary heart disease.

Authors:  H E Miettinen; K Korpela; L Hämäläinen; K Kontula
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132
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