| Literature DB >> 30632146 |
V R Fonseca1,2, L Graca1,3.
Abstract
The identification that T follicular helper (Tfh) cells is critical for the emergence of germinal centre responses prompted the study of CXCR5-expressing CD4+ T cell subsets in autoimmunity. However, circulating CXCR5-expressing T cells are heterogeneous by containing Forkhead box protein 3 (FoxP3)+ T follicular regulatory (Tfr) cells in addition to bona fide Tfh cells. Such heterogeneity may hamper the analysis of the contribution of specific follicular T cell subsets for autoimmune pathogenesis. Therefore, separate assessment of Tfh and Tfr populations offer greater opportunities for stratification of autoimmune patients, such as Sjögren's syndrome patients.Entities:
Keywords: Foxp3; Sjögren’s syndrome; T follicular helper cells; T follicular regulatory cells
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Year: 2019 PMID： 30632146 PMCID： PMC6378382 DOI： 10.1111/cei.13245
Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330