Nelson Andrade1,2, Sara Andrade1,2, Claúdia Silva1,2, Ilda Rodrigues1, Luísa Guardão1, João T Guimarães1,3,4, Elisa Keating1,5, Fátima Martel6,7. 1. Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine of Porto, University of Porto, Porto, Portugal. 2. Instituto de Investigação e Inovação em Saúde (I3S), University of Porto, Porto, Portugal. 3. Department of Clinical Pathology, São João Hospital Centre, Porto, Portugal. 4. Institute of Public Health, University of Porto, Porto, Portugal. 5. CINTESIS, Center for Research in Health Technologies and Information Systems, University of Porto, Porto, Portugal. 6. Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine of Porto, University of Porto, Porto, Portugal. fmartel@med.up.pt. 7. Instituto de Investigação e Inovação em Saúde (I3S), University of Porto, Porto, Portugal. fmartel@med.up.pt.
Abstract
PURPOSE: Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model. METHODS: Adult male Sprague-Dawley rats (220-310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks. RESULTS: Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysin rats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin. CONCLUSIONS: Chrysin was able to protect against some of the MS features induced by fructose-feeding.
PURPOSE:Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenolchrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model. METHODS: Adult male Sprague-Dawley rats (220-310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks. RESULTS:Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysinrats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin. CONCLUSIONS:Chrysin was able to protect against some of the MS features induced by fructose-feeding.
Authors: Laia Vilà; Alba Rebollo; Gunnar S Ađalsteisson; Marta Alegret; Manuel Merlos; Nuria Roglans; Juan C Laguna Journal: Toxicol Appl Pharmacol Date: 2010-11-29 Impact factor: 4.219
Authors: Paula D Prince; Cecilia Rodríguez Lanzi; Jorge E Toblli; Rosana Elesgaray; Patricia I Oteiza; César G Fraga; Monica Galleano Journal: Free Radic Biol Med Date: 2015-11-10 Impact factor: 7.376
Authors: Sarayu A Pai; Elvis Adrian Martis; Renuka P Munshi; Malvika S Gursahani; Snehal N Mestry; Archana R Juvekar Journal: J Tradit Complement Med Date: 2019-09-06