Clinical observation on tranexamic acid combined with reduced glutathione for the treatment of chloasma.

To observe and analyze the efficacy of tranexamic acid combined with reduced glutathione in chloasma treatment. The 180 patients diagnosed with chloasma and treated in our hospital from June 2015 to March 2018 were enrolled as study subjects and randomly divided into treatment group (90 cases) and control group (90 cases) using simple digital table method. Where, the control group was treated with pure topical therapy of hydroquinone ointment, and the treatment group was treated with intradermal injection of tranexamic acid and glutathione. The two groups were observed and compared in terms of treatment efficacy. Comparison of the overall treatment efficacy of the two groups shows that the treatment group is superior to the control group, p<0.05; observation of chloasma severity and chloasma area in the two groups shows that the treatment group has obvious advantages over the control group, p<0.05. The combination of reduced glutathione and tranexamic acid in chloasma treatment can better improve the overall treatment efficacy, lower the severity of the disease, and reduce the chloasma area.

RCT Entities:   Population Interventions Outcomes