Cristina Nombela1, Andrés Lozano2,3, Clara Villanueva4, Juan A Barcia5. 1. Department of Neurosurgery, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain, cristina.nombela@salud.madrid.org. 2. Toronto Western Research Institute, Krembil Discovery Tower, University Health Network, Toronto, Ontario, Canada. 3. Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. 4. Department of Neurology, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain. 5. Department of Neurosurgery, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain.
Abstract
BACKGROUND/AIM: The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS: A PD patient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere. RESULTS: Compared to baseline, 2-month follow-up after GPi stimulation was associated with motor improvements, whereas partial improvements in cognitive functions were observed 3 months after the addition of NBM stimulation to GPi stimulation. CONCLUSION: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.
BACKGROUND/AIM: The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. METHODS: A PDpatient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere. RESULTS: Compared to baseline, 2-month follow-up after GPi stimulation was associated with motor improvements, whereas partial improvements in cognitive functions were observed 3 months after the addition of NBM stimulation to GPi stimulation. CONCLUSION: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.
Authors: Christine Daniels; Frank Steigerwald; Philipp Capetian; Cordula Matthies; Uwe Malzahn; Peter U Heuschmann; Jens Volkmann Journal: Neurol Res Pract Date: 2020-10-19
Authors: I Daria Bogdan; D L Marinus Oterdoom; Teus van Laar; Rients B Huitema; Vincent J Odekerken; Judith A Boel; Rob M A de Bie; J Marc C van Dijk Journal: J Clin Med Date: 2022-01-11 Impact factor: 4.241