Literature DB >> 30627922

Use of stem cells and growth factors in rotator cuff tendon repair.

Dimitrios Tsekes1, Georgios Konstantopoulos2, Wasim S Khan1, Daniel Rossouw3, Mike Elvey4, Jagwant Singh1.   

Abstract

The management of rotator cuff tears continues to prove challenging for orthopaedic surgeons. Such tears affect most age groups and can lead to significant morbidity in patients. The aetiology of these tears is likely to be multifactorial; however, an understanding of the mechanisms involved is still under review. Despite advancements in surgical operative techniques and the materials used, post-operative recurrence rates after surgical repair remain high. A growing area of research surrounds biological adjuncts used to improve the healing potential of the repaired tissues. This review of recent publications focuses on the strengths and limitations of using stem cells and growth factors in rotator cuff repair.

Entities:  

Keywords:  Growth factors; Mesenchymal stem cells; Rotator cuff tears

Mesh:

Substances:

Year:  2019        PMID: 30627922     DOI: 10.1007/s00590-019-02366-x

Source DB:  PubMed          Journal:  Eur J Orthop Surg Traumatol        ISSN: 1633-8065


  5 in total

1.  Novel Use of Intraarticular Granulocyte Colony Stimulating Factor (hG-CSF) Combined with Activated Autologous Peripheral Blood Stem Cells Mobilized with Systemic hG-CSF: Safe and Efficient in Early Osteoarthritis.

Authors:  Konstantinos I Papadopoulos; Mantana Paisan; Warachaya Sutheesophon; Thana Turajane
Journal:  Cartilage       Date:  2021-10-12       Impact factor: 3.117

Review 2.  Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine.

Authors:  Eckhard U Alt; Glenn Winnier; Alexander Haenel; Ralf Rothoerl; Oender Solakoglu; Christopher Alt; Christoph Schmitz
Journal:  Cells       Date:  2020-04-29       Impact factor: 6.600

3.  Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells.

Authors:  Drew W Koch; Alix K Berglund; Kristen M Messenger; Jessica M Gilbertie; Ilene M Ellis; Lauren V Schnabel
Journal:  Front Vet Sci       Date:  2022-08-11

4.  [Effect of microfracture combined with biomimetic hydrogel scaffold on rotator cuff tendon-to-bone healing in rabbits].

Authors:  Chenglong Huang; Song Zhao; Biao Cheng; Gang Chen; Jieen Pan
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2020-09-15

5.  Safety and efficacy of treating symptomatic, partial-thickness rotator cuff tears with fresh, uncultured, unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) isolated at the point of care: a prospective, randomized, controlled first-in-human pilot study.

Authors:  Jason L Hurd; Tiffany R Facile; Jennifer Weiss; Matthew Hayes; Meredith Hayes; John P Furia; Nicola Maffulli; Glenn E Winnier; Christopher Alt; Christoph Schmitz; Eckhard U Alt; Mark Lundeen
Journal:  J Orthop Surg Res       Date:  2020-03-30       Impact factor: 2.359

  5 in total

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