Literature DB >> 30626712

Challenges and strategies for developing efficacious and long-lasting malaria vaccines.

James G Beeson1,2,3, Liriye Kurtovic4,2, Carlota Dobaño5, D Herbert Opi4,2, Jo-Anne Chan4, Gaoqian Feng4,3, Michael F Good6, Linda Reiling4, Michelle J Boyle1,7.   

Abstract

Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2019        PMID： 30626712     DOI： 10.1126/scitranslmed.aau1458

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  34 in total

Review 1.  Systems biology of malaria explored with nonhuman primates.

Authors:  Mary R Galinski
Journal:  Malar J       Date:  2022-06-07       Impact factor: 3.469

2.  An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes.

Authors:  Amed Ouattara; Ankit Dwivedi; Matthew Adams; Amadou Niangaly; Matthew B Laurens; Myaing M Nyunt; Christopher V Plowe; Abdoulaye Djimde; Shannon Takala-Harrison; Joana C Silva
Journal:  Microorganisms       Date:  2022-05-25

3.  Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.

Authors:  Jo-Anne Chan; Jessica R Loughland; Lauren de la Parte; Satomi Okano; Isaac Ssewanyana; Mayimuna Nalubega; Felistas Nankya; Kenneth Musinguzi; John Rek; Emmanuel Arinaitwe; Peta Tipping; Peter Bourke; Dean Andrew; Nicholas Dooley; Arya SheelaNair; Bruce D Wines; P Mark Hogarth; James G Beeson; Bryan Greenhouse; Grant Dorsey; Moses Kamya; Gunter Hartel; Gabriela Minigo; Margaret Feeney; Prasanna Jagannathan; Michelle J Boyle
Journal:  Nat Commun       Date:  2022-07-18       Impact factor: 17.694

4.  Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria.

Authors:  Fauzia K Musasia; Irene N Nkumama; Roland Frank; Victor Kipkemboi; Martin Schneider; Kennedy Mwai; Dennis O Odera; Micha Rosenkranz; Kristin Fürle; Domitila Kimani; James Tuju; Patricia Njuguna; Mainga Hamaluba; Melissa C Kapulu; Hedda Wardemann; Faith H A Osier
Journal:  Nat Commun       Date:  2022-07-14       Impact factor: 17.694

Review 5.  Human unconventional T cells in Plasmodium falciparum infection.

Authors:  Mathias Schmaler; Nina Orlova-Fink; Tobias Rutishauser; Salim Abdulla; Claudia Daubenberger
Journal:  Semin Immunopathol       Date:  2020-02-19       Impact factor: 9.623

Review 6.  Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases.

Authors:  Lampouguin Yenkoidiok-Douti; Christopher M Jewell
Journal:  ACS Biomater Sci Eng       Date:  2020-01-12

7.  Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study.

Authors:  Jason Carnes; William Chad Young; Lindsay Carpp; Daniel E Neafsey; Claudia Daubenberger; M Juliana McElrath; Carlota Dobaño; Ken Stuart; Raphael Gottardo; Gemma Moncunill; Stephen De Rosa; Joseph J Campo; Augusto Nhabomba; Maxmillian Mpina; Chenjerai Jairoce; Greg Finak; Paige Haas; Carl Muriel; Phu Van; Héctor Sanz; Sheetij Dutta; Benjamin Mordmüller; Selidji T Agnandji; Núria Díez-Padrisa; Nana Aba Williams; John J Aponte; Clarissa Valim
Journal:  Elife       Date:  2022-01-21       Impact factor: 8.713

8.  Antibody Combinations Targeting the Essential Antigens CyRPA, RH5, and MSP-119 Potently Neutralize Plasmodium falciparum Clinical Isolates From India and Africa.

Authors:  Hina Singh; Syed Yusuf Mian; Alok K Pandey; Sri Krishna; Gaurav Anand; K Sony Reddy; Neha Chaturvedi; Vanndita Bahl; Nidhi Hans; Man Mohan Shukla; Quique Bassat; Alfredo Mayor; Kazutoyo Miura; Praveen K Bharti; Carole Long; Neeru Singh; Virander Singh Chauhan; Deepak Gaur
Journal:  J Infect Dis       Date:  2021-06-04       Impact factor: 5.226

9.  Screening and characterization of hypothetical proteins of Plasmodium falciparum as novel vaccine candidates in the fight against malaria using reverse vaccinology.

Authors:  Claire Aguttu; Brenda Apio Okech; Ambrose Mukisa; George William Lubega
Journal:  J Genet Eng Biotechnol       Date:  2021-07-16

Review 10.  Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria.

Authors:  Stephen Tukwasibwe; Annettee Nakimuli; James Traherne; Olympe Chazara; Jyothi Jayaraman; John Trowsdale; Ashley Moffett; Prasanna Jagannathan; Philip J Rosenthal; Stephen Cose; Francesco Colucci
Journal:  Cell Mol Immunol       Date:  2020-06-15       Impact factor: 11.530
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