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Literature DB >> 30625309

A "Connexin" Responsible for the Fatal Attraction of Cancer to Bone.

David L Waning¹, Theresa A Guise², Khalid S Mohammad³.

Abstract

Tumor cell interactions with the bone microenvironment are vital for the establishment and progression of bone metastases. Recently in Cancer Cell, Wang et al. (2018) showed that cells of the osteoblast lineage are critical for the delivery of calcium to tumor cells through gap junctions, pointing toward potential therapies for bone metastases.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Connexins
Calcium

Year: 2019 PMID： 30625309 PMCID： PMC6443097 DOI： 10.1016/j.cmet.2018.12.014

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

9 in total

1. The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability.

Authors: Hai Wang; Lin Tian; Jun Liu; Amit Goldstein; Igor Bado; Weijie Zhang; Benjamin R Arenkiel; Zonghai Li; Meng Yang; Shiyu Du; Hong Zhao; David R Rowley; Stephen T C Wong; Zbigniew Gugala; Xiang H-F Zhang
Journal: Cancer Cell Date: 2018-11-12 Impact factor: 31.743

Review 2. Cancer to bone: a fatal attraction.

Authors: Katherine N Weilbaecher; Theresa A Guise; Laurie K McCauley
Journal: Nat Rev Cancer Date: 2011-05-19 Impact factor: 60.716

3. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.

Authors: Hai Wang; Cuijuan Yu; Xia Gao; Thomas Welte; Aaron M Muscarella; Lin Tian; Hong Zhao; Zhen Zhao; Shiyu Du; Jianning Tao; Brendan Lee; Thomas F Westbrook; Stephen T C Wong; Xin Jin; Jeffrey M Rosen; C Kent Osborne; Xiang H-F Zhang
Journal: Cancer Cell Date: 2015-01-15 Impact factor: 31.743

4. Metastatic breast cancer induces an osteoblast inflammatory response.

Authors: Michelle Kinder; Elizabeth Chislock; Karen M Bussard; Laurie Shuman; Andrea M Mastro
Journal: Exp Cell Res Date: 2007-10-04 Impact factor: 3.905

5. Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor β (TGFβ) signaling.

Authors: Terese Karlsson; Reshma Sundar; Anders Widmark; Maréne Landström; Emma Persson
Journal: Prostate Date: 2018-01-31 Impact factor: 4.104

6. Calcium-Sensing Receptor Tumor Expression and Lethal Prostate Cancer Progression.

Authors: Thomas U Ahearn; Nairi Tchrakian; Kathryn M Wilson; Rosina Lis; Elizabeth Nuttall; Howard D Sesso; Massimo Loda; Edward Giovannucci; Lorelei A Mucci; Stephen Finn; Irene M Shui
Journal: J Clin Endocrinol Metab Date: 2016-04-26 Impact factor: 5.958

Review 7. Hallmarks of cancer: the next generation.

Authors: Douglas Hanahan; Robert A Weinberg
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

8. Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation.

Authors: Cédric Boudot; Lucie Hénaut; Ursula Thiem; Sandra Geraci; Mariangela Galante; Paulo Saldanha; Zuzana Saidak; Isabelle Six; Philippe Clézardin; Said Kamel; Romuald Mentaverri
Journal: Oncotarget Date: 2017-04-10

9. Transforming growth factor-β1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway.

Authors: Wenjing Liu; Yujia Cui; Jianxun Sun; Linyi Cai; Jing Xie; Xuedong Zhou
Journal: Biosci Rep Date: 2018-12-14 Impact factor: 3.840

9 in total

4 in total