Dejan Jakimovski1, Ralph Hb Benedict2, Karen Marr1, Sirin Gandhi1, Niels Bergsland1, Bianca Weinstock-Guttman2, Robert Zivadinov3. 1. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA. 2. Jacobs Multiple Sclerosis Center for Treatment and Research, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA. 3. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging, Clinical Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Abstract
BACKGROUND: The cognitive performance in multiple sclerosis (MS) patients declines with aging, longer disease duration, and possibly cardiovascular comorbidities. OBJECTIVES: We investigated whether lower total cerebral arterial blood flow (CABF) measured at the level of the carotid and vertebral arteries may contribute to worse cognitive performance in 132 MS patients and 47 healthy controls. METHODS: Total CABF was evaluated with extracranial Doppler, whereas structural T2-lesion volume (LV) and gray matter volume (GMV) were measured on 3T MRI. The cognitive performance was assessed by Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test-Revised (BVMT-R), and California Verbal Learning Test-Second Edition (CVLT-II). Analysis of covariance, partial correlation, and regression models were used to test the differences between study groups and cognition/CABF correlations. False discovery rate (FDR)-corrected (Benjamini-Hochberg) p-values (i.e. q-values) less than 0.05 were considered significant. RESULTS: Association between lower total CABF and the lower cognitive performance was observed only in MS patients (r = 0.318, q < 0.001 and r = 0.244, q = 0.012 for SDMT and BVMT-R, respectively). Lower GMV, higher T2-LV, and CABF were significantly associated with poorer performance on the processing speed measure of SDMT (adjusted R2 = 0.295, t-statistics = 2.538, standardized β = 0.203, and q = 0.020), but not with memory tests. Cognitively impaired MS patients had lower total CABF compared to cognitively preserved (884.5 vs 1020.2 mL/min, q = 0.008). CONCLUSION: Cognitively impaired MS patients presented with lower total CABF. Altered CABF may be a result of reduced metabolic rate and might contribute to abnormal cognitive aging in MS.
BACKGROUND: The cognitive performance in multiple sclerosis (MS) patientsdeclines with aging, longer disease duration, and possibly cardiovascular comorbidities. OBJECTIVES: We investigated whether lower total cerebral arterial blood flow (CABF) measured at the level of the carotid and vertebral arteries may contribute to worse cognitive performance in 132 MSpatients and 47 healthy controls. METHODS: Total CABF was evaluated with extracranial Doppler, whereas structural T2-lesion volume (LV) and gray matter volume (GMV) were measured on 3T MRI. The cognitive performance was assessed by Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test-Revised (BVMT-R), and California Verbal Learning Test-Second Edition (CVLT-II). Analysis of covariance, partial correlation, and regression models were used to test the differences between study groups and cognition/CABF correlations. False discovery rate (FDR)-corrected (Benjamini-Hochberg) p-values (i.e. q-values) less than 0.05 were considered significant. RESULTS: Association between lower total CABF and the lower cognitive performance was observed only in MSpatients (r = 0.318, q < 0.001 and r = 0.244, q = 0.012 for SDMT and BVMT-R, respectively). Lower GMV, higher T2-LV, and CABF were significantly associated with poorer performance on the processing speed measure of SDMT (adjusted R2 = 0.295, t-statistics = 2.538, standardized β = 0.203, and q = 0.020), but not with memory tests. Cognitively impaired MSpatients had lower total CABF compared to cognitively preserved (884.5 vs 1020.2 mL/min, q = 0.008). CONCLUSION: Cognitively impaired MSpatients presented with lower total CABF. Altered CABF may be a result of reduced metabolic rate and might contribute to abnormal cognitive aging in MS.
Authors: Angela L Jefferson; Jayandra J Himali; Rhoda Au; Sudha Seshadri; Charles Decarli; Christopher J O'Donnell; Philip A Wolf; Warren J Manning; Alexa S Beiser; Emelia J Benjamin Journal: Am J Cardiol Date: 2011-08-30 Impact factor: 2.778
Authors: Ponnada A Narayana; Yuxiang Zhou; Khader M Hasan; Sushmita Datta; Xiaojun Sun; Jerry S Wolinsky Journal: Mult Scler Date: 2013-07-08 Impact factor: 6.312
Authors: P Belov; D Jakimovski; J Krawiecki; C Magnano; J Hagemeier; L Pelizzari; B Weinstock-Guttman; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2017-12-07 Impact factor: 3.825
Authors: L Pelizzari; D Jakimovski; M M Laganà; N Bergsland; J Hagemeier; G Baselli; B Weinstock-Guttman; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2018-07-26 Impact factor: 3.825
Authors: Olivia A Skrobot; Johannes Attems; Margaret Esiri; Tibor Hortobágyi; James W Ironside; Rajesh N Kalaria; Andrew King; George A Lammie; David Mann; James Neal; Yoav Ben-Shlomo; Patrick G Kehoe; Seth Love Journal: Brain Date: 2016-11-01 Impact factor: 13.501
Authors: Wesley K Lefferts; Alexander J Rosenberg; Elizabeth C Schroeder; Georgios Grigoriadis; Brian M Sandroff; Robert W Motl; Tracy Baynard Journal: Int J MS Care Date: 2021-01-21
Authors: Dejan Jakimovski; Bianca Weinstock-Guttman; Shumita Roy; Michael Jaworski; Laura Hancock; Alissa Nizinski; Pavitra Srinivasan; Tom A Fuchs; Kinga Szigeti; Robert Zivadinov; Ralph H B Benedict Journal: Front Aging Neurosci Date: 2019-05-10 Impact factor: 5.750
Authors: Antonio Reia; Martina Petruzzo; Fabrizia Falco; Teresa Costabile; Matteo Conenna; Antonio Carotenuto; Maria Petracca; Giuseppe Servillo; Roberta Lanzillo; Vincenzo Brescia Morra; Marcello Moccia Journal: Brain Sci Date: 2021-04-16