Literature DB >> 3062475

Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats.

R F Berman1, H Goldman, H J Altman.   

Abstract

Studies of regional cerebral blood flow (rCBF) were carried out in male, Sprague-Dawley rats at ages 6, 12 and 24 months. These animals were characterized behaviorally for their ability to learn a complex 14-choice sequential T-maze (i.e., Stone maze) for food reward. Old animals (i.e., 24 month) demonstrated a clear and consistent impairment in maze performance which correlated significantly with decreased cortical blood flow. The results are discussed in relation to cerebral blood flow studies in aging humans and as they relate to the use of rats, the Sprague-Dawley strain in particular, to study brain aging.

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Year:  1988        PMID： 3062475     DOI： 10.1016/s0197-4580(88)80134-9

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  7 in total

1.  Neurometabolic coupling in the lateral geniculate nucleus changes with extended age.

Authors:  Baowang Li; Ralph D Freeman
Journal:  J Neurophysiol       Date:  2010-05-12       Impact factor: 2.714

2.  Development of a water-escape motivated version of the Stone T-maze for mice.

Authors:  P J Pistell; D K Ingram
Journal:  Neuroscience       Date:  2009-12-22       Impact factor: 3.590

Review 3.  Age-related changes in brain support cells: Implications for stroke severity.

Authors:  Farida Sohrabji; Shameena Bake; Danielle K Lewis
Journal:  Neurochem Int       Date:  2013-06-28       Impact factor: 3.921

4.  Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography.

Authors:  Yuandong Li; Woo June Choi; Wei Wei; Shaozhen Song; Qinqin Zhang; Jialing Liu; Ruikang K Wang
Journal:  Neurobiol Aging       Date:  2018-06-22       Impact factor: 4.673

5.  Angiogenesis in old-aged subjects after ischemic stroke: a cautionary note for investigators.

Authors:  Eugen B Petcu; Robert A Smith; Rodica I Miroiu; Maria M Opris
Journal:  J Angiogenes Res       Date:  2010-11-26

6.  Compromised microvascular oxygen delivery increases brain tissue vulnerability with age.

Authors:  Mohammad Moeini; Xuecong Lu; Pramod K Avti; Rafat Damseh; Samuel Bélanger; Frédéric Picard; David Boas; Ashok Kakkar; Frédéric Lesage
Journal:  Sci Rep       Date:  2018-05-29       Impact factor: 4.379

7.  Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.

Authors:  Amir Hadanny; Malka Daniel-Kotovsky; Gil Suzin; Merav Catalogna; Kobi Dagan; Yafit Hachmo; Ramzia Abu Hamed; Efrat Sasson; Gregory Fishlev; Erez Lang; Nir Polak; Keren Doenyas; Mony Friedman; Sigal Tal; Yonatan Zemel; Yair Bechor; Shai Efrati
Journal:  Aging (Albany NY)       Date:  2020-06-26       Impact factor: 5.682
  7 in total

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