| Literature DB >> 30624731 |
Yoshitaka Matsumoto1,2, Yoshiya Furusawa3, Mizuho Aoki-Nakano3, Naruhiro Matsufuji3, Ryoichi Hirayama3, Tatsuaki Kanai4, Koichi Ando4, Hideyuki Sakurai1,2.
Abstract
Hypofractionated carbon-ion therapy has been applied to treatment of several tumours. In this case, relative biological effectiveness (RBE) at high dose region must be considered, however, the RBE calculated physically has been not verified biologically. In this study, spheroid technique was adopted to estimate RBE in wide dose range. Cells were irradiated with X-rays and heavy-ions with LET of 13, 35, 100 and 300 keV/μm with monolayer and spheroid condition. Surviving fractions in wide dose range (0-15 Gy) were obtained to combined monolayer with spheroid survival data. The linear-quadratic and multi-target single-hit equation fitted well in survival data at low dose, and high dose region, respectively. A multi-process equation showed best fitting for survival data in wide dose range. RBE values of heavy-ions could be estimated by combination of monolayer and spheroid data. The values converged at 1.1-1.4 and varied by LET values at high and low dose region, respectively.Entities:
Mesh：
Substances：
Year: 2019 PMID： 30624731 DOI： 10.1093/rpd/ncy269
Source DB: PubMed Journal: Radiat Prot Dosimetry ISSN： 0144-8420 Impact factor: 0.972