Literature DB >> 3062466

Preservation and loss of spatial memory in aged rats and humans: implications for the analysis of memory dysfunction in dementia.

W W Beatty1.   

Abstract

Research with laboratory rats and humans demonstrating that the usual age-related deficits in spatial working memory can be attenuated or eliminated by prior training earlier in adult life is reviewed and possible mechanisms for this phenomenon are considered. A new technique for measuring remote memory for spatial information in humans is described and preliminary results with demented patients are discussed.

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Year:  1988        PMID： 3062466     DOI： 10.1016/s0197-4580(88)80113-1

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  3 in total

1.  Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

Authors:  M E Bach; M Barad; H Son; M Zhuo; Y F Lu; R Shih; I Mansuy; R D Hawkins; E R Kandel
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Chronic, severe hypertension does not impair spatial learning and memory in Sprague-Dawley rats.

Authors:  I Kadish; T van Groen; J M Wyss
Journal:  Learn Mem       Date:  2001 Mar-Apr       Impact factor: 2.460

3.  Intrahippocampal cholinergic grafts in aged rats compensate impairments in a radial maze and in a place learning task.

Authors:  F Schenk; B Contant; P Werffeli
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972
  3 in total

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