Literature DB >> 30624124

Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

Miaomiao Ge1, Lu Zhang1, Lina Cao1, Chunfeng Xie2, Xiaoting Li2, Yuan Li2, Yu Meng2, Yue Chen2, Xiaoqian Wang2, Jiaqi Chen2, Qi Zhang2, Jihong Shao1, Caiyun Zhong2,3.   

Abstract

Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity. Gastric cancer is common cancer worldwide. The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. The results found that tumorsphere formation and the expression levels of gastric cancer stem cells (CSCs) markers were significantly decreased after SFN treatment. SFN also exerted inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs. Intriguingly, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs. Upregulation of Sonic Hh pathway diminished the inhibitory effects of SFN on gastric CSCs. Collectively, these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of Sonic Hh pathway, which might be an promising agent for gastric cancer intervention.

Entities:  

Keywords:  Sonic hedgehog pathway; Sulforaphane; gastric cancer stem cells; suppression

Mesh：

Substances：

Year:  2019        PMID： 30624124     DOI： 10.1080/09637486.2018.1545012

Source DB:  PubMed          Journal:  Int J Food Sci Nutr        ISSN： 0963-7486            Impact factor:   3.833


  10 in total

Review 1.  Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy.

Authors:  Elham Patrad; Solmaz Khalighfard; Taghi Amiriani; Vahid Khori; Ali Mohammad Alizadeh
Journal:  Cell Oncol (Dordr)       Date:  2022-09-23       Impact factor: 7.051

2.  Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis.

Authors:  Chunfeng Xie; Jianyun Zhu; Ye Jiang; Jiaqi Chen; Xueqi Wang; Shanshan Geng; Jieshu Wu; Caiyun Zhong; Xiaoting Li; Zili Meng
Journal:  Theranostics       Date:  2019-07-09       Impact factor: 11.556

3.  Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells.

Authors:  Yuan Wang; Huazhang Wu; Nannan Dong; Xu Su; Mingxiu Duan; Yaqin Wei; Jun Wei; Gaofeng Liu; Qingjie Peng; Yunli Zhao
Journal:  Sci Rep       Date:  2021-01-28       Impact factor: 4.379

4.  Identification of sulforaphane regulatory network in hepatocytes by microarray data analysis based on GEO database.

Authors:  Lei Gao; Jinshen Wang; Yuhua Zhao; Junhua Liu; Da Cai; Xiao Zhang; Yutao Wang; Shuqiu Zhang
Journal:  Biosci Rep       Date:  2021-02-26       Impact factor: 3.840

5.  Therapeutic Mechanism of Lapatinib Combined with Sulforaphane on Gastric Cancer.

Authors:  Huixing Yi; Zheming Li; Xiaoxi Liu; Shijie Dai; Shouye Li
Journal:  Evid Based Complement Alternat Med       Date:  2021-09-18       Impact factor: 2.629

Review 6.  Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies.

Authors:  Mahshid Deldar Abad Paskeh; Shafagh Asadi; Amirhossein Zabolian; Hossein Saleki; Mohammad Amin Khoshbakht; Sina Sabet; Mohamad Javad Naghdi; Mehrdad Hashemi; Kiavash Hushmandi; Milad Ashrafizadeh; Sepideh Mirzaei; Ali Zarrabi; Gautam Sethi
Journal:  Int J Mol Sci       Date:  2021-10-28       Impact factor: 5.923

Review 7.  Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers.

Authors:  Saikat Mitra; Talha Bin Emran; Deepak Chandran; B M Redwan Matin Zidan; Rajib Das; Sukamto S Mamada; Ayu Masyita; Mirnawati Salampe; Firzan Nainu; Mayeen Uddin Khandaker; Abubakr M Idris; Jesus Simal-Gandara
Journal:  Front Nutr       Date:  2022-08-04

Review 8.  Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies.

Authors:  Fahadul Islam; Saikat Mitra; Talha Bin Emran; Zidan Khan; Nikhil Nath; Rajib Das; Rohit Sharma; Ahmed Abdullah Al Awadh; Moon Nyeo Park; Bonglee Kim
Journal:  Molecules       Date:  2022-09-03       Impact factor: 4.927

Review 9.  The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer.

Authors:  Ying Yang; Wen-Jian Meng; Zi-Qiang Wang
Journal:  Front Oncol       Date:  2022-09-15       Impact factor: 5.738

Review 10.  Brassicaceae-Derived Anticancer Agents: Towards a Green Approach to Beat Cancer.

Authors:  Luigi Mandrich; Emilia Caputo
Journal:  Nutrients       Date:  2020-03-24       Impact factor: 5.717
  10 in total

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