PURPOSE: To evaluate artifacts in optical coherence tomography angiography (OCT-A) images of multiple sclerosis (MS) patients and healthy controls. MATERIALS AND METHODS: This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. OCT-A was performed using Spectralis® OCT-A prototype, OCT2 (Heidelberg, Germany). The type and frequency of artifacts, the clinical factors associated with them, and their impact on vessel density measurements were assessed. RESULTS: Overall, 385 images from 102 participants were analyzed. The majority of images (97.1%) had some degree of artifact. The most frequent was motion artifact (96.3%), followed by blinking (51.9%), and loss of focus (25.1%). MS patients were more likely to have any artifact vs. controls (OR [95% CI], 3.83 [1.12-12.92]), and were more likely to have motion artifacts with longer disease duration (OR [95% CI], 1.11 [1.03-1.20]) or history of optic neuritis (OR [95% CI], 4.24 [1.19-15.16]). The relative area occupied by the artifact was found to underestimate vessel density measurements in both MS patients and controls. CONCLUSIONS: Artifacts are common with OCT-A imaging using this particular Spectralis® OCT-A prototype and can impact quantitative vascular density metrics. Future studies should review images for artifacts before drawing definitive conclusions.
PURPOSE: To evaluate artifacts in optical coherence tomography angiography (OCT-A) images of multiple sclerosis (MS) patients and healthy controls. MATERIALS AND METHODS: This was a prospective cross-sectional study conducted at the Department of Neurology and the Wilmer Eye Institute at Johns Hopkins Hospital. Subjects included patients with an established diagnosis of MS and healthy volunteers. OCT-A was performed using Spectralis® OCT-A prototype, OCT2 (Heidelberg, Germany). The type and frequency of artifacts, the clinical factors associated with them, and their impact on vessel density measurements were assessed. RESULTS: Overall, 385 images from 102 participants were analyzed. The majority of images (97.1%) had some degree of artifact. The most frequent was motion artifact (96.3%), followed by blinking (51.9%), and loss of focus (25.1%). MSpatients were more likely to have any artifact vs. controls (OR [95% CI], 3.83 [1.12-12.92]), and were more likely to have motion artifacts with longer disease duration (OR [95% CI], 1.11 [1.03-1.20]) or history of optic neuritis (OR [95% CI], 4.24 [1.19-15.16]). The relative area occupied by the artifact was found to underestimate vessel density measurements in both MSpatients and controls. CONCLUSIONS: Artifacts are common with OCT-A imaging using this particular Spectralis® OCT-A prototype and can impact quantitative vascular density metrics. Future studies should review images for artifacts before drawing definitive conclusions.
Authors: Ying Cui; Ying Zhu; Jay C Wang; Yifan Lu; Rebecca Zeng; Raviv Katz; David M Wu; Demetrios G Vavvas; Deeba Husain; Joan W Miller; Leo A Kim; John B Miller Journal: Transl Vis Sci Technol Date: 2019-11-15 Impact factor: 3.283
Authors: Olwen C Murphy; Grigorios Kalaitzidis; Eleni Vasileiou; Angeliki G Filippatou; Jeffrey Lambe; Henrik Ehrhardt; Nicole Pellegrini; Elias S Sotirchos; Nicholas J Luciano; Yihao Liu; Kathryn C Fitzgerald; Jerry L Prince; Peter A Calabresi; Shiv Saidha Journal: Front Neurol Date: 2020-12-15 Impact factor: 4.003
Authors: Axel Petzold; Philipp Albrecht; Laura Balcer; Erik Bekkers; Alexander U Brandt; Peter A Calabresi; Orla Galvin Deborah; Jennifer S Graves; Ari Green; Pearse A Keane; Jenny A Nij Bijvank; Josemir W Sander; Friedemann Paul; Shiv Saidha; Pablo Villoslada; Siegfried K Wagner; E Ann Yeh Journal: Ann Clin Transl Neurol Date: 2021-05-19 Impact factor: 4.511