Gustavo T Silva1, Larissy M Silva2, Anke Bergmann2, Luiz Cs Thuler2,3. 1. Cancer Hospital I, National Cancer Institute, Rio de Janeiro, Brazil. 2. Research Center, National Cancer Institute, Rio de Janeiro, Brazil. 3. Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract
AIM: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival. PATIENTS & METHODS: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan-Meier survival analysis and the risk of death were estimated. RESULTS: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04-1.49; p = 0.013). CONCLUSION: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients.
AIM: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival. PATIENTS & METHODS: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan-Meier survival analysis and the risk of death were estimated. RESULTS: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04-1.49; p = 0.013). CONCLUSION: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLCpatients.
Entities:
Keywords:
bone metastases; histological subtype; incidence; lung cancer; skeletal-related events
Authors: Anita J W M Brouns; Ben H De Bie; Marieke H J van den Beuken-van Everdingen; Anne-Marie C Dingemans; Lizza E L Hendriks Journal: Front Oncol Date: 2020-10-22 Impact factor: 6.244