Literature DB >> 30623670

Paraherquamide J, a new prenylated indole alkaloid from the marine-derived fungus Penicillium janthinellum HK1-6.

Yao-Yao Zheng1,2, Nan-Xing Shen2, Zhao-Yang Liang1,2, Li Shen3,4, Min Chen2, Chang-Yun Wang1,5.   

Abstract

A new prenylated indole alkaloid, named paraherquamide J (1), together with four known compounds (2-5), were isolated from the mangrove rhizosphere soil-derived fungus Penicillium janthinellum HK1-6. The planar structure and relative configuration of 1 were determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. The absolute configuration of 1 was determined by ECD spectra. Compound 2 was first isolated as a natural product and named as paraherquamide K. All isolated metabolites were evaluated for their antibacterial, topoisomerase I (topo I) inhibitory activities and lethality towards brine shrimp Artemia salina.

Entities:  

Keywords:  marine-derived fungus; Penicillium janthinellum; paraherquamide; prenylated indole alkaloid

Mesh：

Substances：

Year:  2019        PMID： 30623670     DOI： 10.1080/14786419.2018.1534105

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  6 in total

Review 1.  Comprehensive Overview on the Chemistry and Biological Activities of Selected Alkaloid Producing Marine-Derived Fungi as a Valuable Reservoir of Drug Entities.

Authors:  Fadia S Youssef; Jesus Simal-Gandara
Journal:  Biomedicines       Date:  2021-04-28

Review 2.  The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade.

Authors:  Danyu Zhang; Shoujie Li; Mohan Fan; Changqi Zhao
Journal:  Drug Des Devel Ther       Date:  2022-10-12       Impact factor: 4.319

3.  Thiazolo[5,4-b]pyridine Alkaloid and Seven ar-Bisabol Sesquiterpenes Produced by the Endophytic Fungus Penicillium janthinellum.

Authors:  Wen-Jing Wang; Liang-Xiu Liao; Ze-Diao Huang; Fu-Ting Wei; Xiao-Long Yang
Journal:  ACS Omega       Date:  2022-09-21

Review 4.  Marine Indole Alkaloids-Isolation, Structure and Bioactivities.

Authors:  Yong Hu; Siling Chen; Fang Yang; Shuai Dong
Journal:  Mar Drugs       Date:  2021-11-24       Impact factor: 5.118

Review 5.  Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities.

Authors:  Joko Tri Wibowo; Peni Ahmadi; Siti Irma Rahmawati; Asep Bayu; Masteria Yunovilsa Putra; Anake Kijjoa
Journal:  Mar Drugs       Date:  2021-12-21       Impact factor: 5.118

6.  HR-LC-ESI-Orbitrap-MS-Based Metabolic Profiling Coupled with Chemometrics for the Discrimination of Different Echinops spinosus Organs and Evaluation of Their Antioxidant Activity.

Authors:  Amel Bouzabata; Paola Montoro; Katarzyna Angelika Gil; Sonia Piacente; Fadia S Youssef; Nawal M Al Musayeib; Geoffrey A Cordell; Mohamed L Ashour; Carlo Ignazio Giovanni Tuberoso
Journal:  Antioxidants (Basel)       Date:  2022-02-24
  6 in total

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