Literature DB >> 3062269

Hypoprothrombinemia due to cefamandole.

V M Conraads1, H E Demey, L G Heytens, L L Bossaert.   

Abstract

Two patients are described with severe coagulation disturbances, in one instance leading to extensive skin bleeding, secondary to the use of cefamandole. This cefalosporin antibiotic carries the same N-methylthiotetrazole side chain as moxalactam. Pathogenetic mechanisms leading to hypoprothrombinemia, its prevention and treatment are discussed.

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Year:  1988        PMID： 3062269     DOI： 10.1007/bf01727668

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  7 in total

1.  N-methyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia.

Authors:  J J Lipsky
Journal:  Lancet       Date:  1983-07-23       Impact factor: 79.321

2.  The spectrum of vitamin K deficiency.

Authors:  J E Ansell; R Kumar; D Deykin
Journal:  JAMA       Date:  1977-07-04       Impact factor: 56.272

Review 3.  Potential for bleeding with the new beta-lactam antibiotics.

Authors:  F R Sattler; M R Weitekamp; J O Ballard
Journal:  Ann Intern Med       Date:  1986-12       Impact factor: 25.391

4.  Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats.

Authors:  J J Lipsky; J C Lewis; W J Novick
Journal:  Antimicrob Agents Chemother       Date:  1984-03       Impact factor: 5.191

5.  Inhibition of vitamin K-dependent carboxylase in vitro by cefamandole and its structural analogs.

Authors:  L Uotila; J W Suttie
Journal:  J Infect Dis       Date:  1983-09       Impact factor: 5.226

6.  Pharmacokinetics and protein binding of cefamandole and its 1-methyl-1 H-tetrazole-5-thiol side chain in subjects with normal and impaired renal function.

Authors:  G R Aronoff; R L Wolen; B D Obermeyer; H R Black
Journal:  J Infect Dis       Date:  1986-06       Impact factor: 5.226

7.  Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit?

Authors:  G Agnelli; A Del Favero; P Parise; R Guerciolini; B Pasticci; G G Nenci; F Ofosu
Journal:  Antimicrob Agents Chemother       Date:  1986-06       Impact factor: 5.191
  7 in total

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