Rudolf Hoermann1, Mark Ng Tang Fui2,3, Jesse C Krakauer4, Nir Y Krakauer5, Mathis Grossmann2,3. 1. Department of Medicine Austin Health, University of Melbourne, Heidelberg, VIC, Australia. rudolf.hoermann@gmail.com. 2. Department of Medicine Austin Health, University of Melbourne, Heidelberg, VIC, Australia. 3. Department of Endocrinology, Austin Health, Heidelberg, VIC, Australia. 4. Metro Detroit Diabetes and Endocrinology, Southfield, MI, USA. 5. Department of Civil Engineering, City College of New York, New York, NY, USA.
Abstract
BACKGROUND: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI. OBJECTIVES: Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference. INTERVENTION: Secondary analysis of a 56-week RCT in 100 dieting obese men with low-normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up. RESULTS: At the end of the trial period, ABSI-unlike weight, BMI or waist circumference-had significantly decreased in the treatment group, compared with placebo (mean adjusted difference -0.18 [95% CI: -0.32, -0.05] × 10-2 m11/6kg-2/3, overall P<0.001). Changes in ABSI during the active trial phase correlated with changes in fat mass (tau = 0.18, P = 0.02), and not with lean mass (tau = -0.11, P = 0.14), BMI (tau = 0.10, P = 0.17), or visceral fat (tau = 0.07, P = 0.37). ABSI baseline values were positively correlated with waist circumference (tau = 0.21, P = 0.002) and visceral fat (tau = 0.18, P = 0.009), correlated inversely with lean mass (tau = -0.21, P = 0.002), and were uncorrelated with BMI (tau = -0.10, P = 0.15) and fat mass (tau = 0.01, P = 0.83). Two years after cessation of treatment, ABSI again reflected body composition as the between-group differences in all parameters did not persist. CONCLUSIONS: A readily obtainable anthropomorphic measure, ABSI reflects the differential loss of fat mass mediated by testosterone in dieting obese men more closely than BMI or waist circumference. It may serve as a clinically useful marker to monitor body composition changes, particularly in response to interventions.
RCT Entities:
BACKGROUND: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI. OBJECTIVES: Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference. INTERVENTION: Secondary analysis of a 56-week RCT in 100 dieting obesemen with low-normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up. RESULTS: At the end of the trial period, ABSI-unlike weight, BMI or waist circumference-had significantly decreased in the treatment group, compared with placebo (mean adjusted difference -0.18 [95% CI: -0.32, -0.05] × 10-2 m11/6kg-2/3, overall P<0.001). Changes in ABSI during the active trial phase correlated with changes in fat mass (tau = 0.18, P = 0.02), and not with lean mass (tau = -0.11, P = 0.14), BMI (tau = 0.10, P = 0.17), or visceral fat (tau = 0.07, P = 0.37). ABSI baseline values were positively correlated with waist circumference (tau = 0.21, P = 0.002) and visceral fat (tau = 0.18, P = 0.009), correlated inversely with lean mass (tau = -0.21, P = 0.002), and were uncorrelated with BMI (tau = -0.10, P = 0.15) and fat mass (tau = 0.01, P = 0.83). Two years after cessation of treatment, ABSI again reflected body composition as the between-group differences in all parameters did not persist. CONCLUSIONS: A readily obtainable anthropomorphic measure, ABSI reflects the differential loss of fat mass mediated by testosterone in dieting obesemen more closely than BMI or waist circumference. It may serve as a clinically useful marker to monitor body composition changes, particularly in response to interventions.
Authors: Sofia Christakoudi; Konstantinos K Tsilidis; David C Muller; Heinz Freisling; Elisabete Weiderpass; Kim Overvad; Stefan Söderberg; Christel Häggström; Tobias Pischon; Christina C Dahm; Jie Zhang; Anne Tjønneland; Jytte Halkjær; Conor MacDonald; Marie-Christine Boutron-Ruault; Francesca Romana Mancini; Tilman Kühn; Rudolf Kaaks; Matthias B Schulze; Antonia Trichopoulou; Anna Karakatsani; Eleni Peppa; Giovanna Masala; Valeria Pala; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; J Ramón Quirós; Antonio Agudo; Maria-Jose Sánchez; Lluís Cirera; Aurelio Barricarte-Gurrea; Pilar Amiano; Ensieh Memarian; Emily Sonestedt; Bas Bueno-de-Mesquita; Anne M May; Kay-Tee Khaw; Nicholas J Wareham; Tammy Y N Tong; Inge Huybrechts; Hwayoung Noh; Elom K Aglago; Merete Ellingjord-Dale; Heather A Ward; Dagfinn Aune; Elio Riboli Journal: Sci Rep Date: 2020-09-03 Impact factor: 4.379