Eleni Margioti1,2, Mary-Helen Kosmidis1, Mary Yannakoulia3, Efthimios Dardiotis4, Georgios Hadjigeorgiou4, Paraskevi Sakka2, Eva Ntanasi3,2, George S Vlachos5, Nikolaos Scarmeas5,6. 1. Laboratory of Cognitive Neuroscience School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece. 2. Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece. 3. Department of Nutrition and Diabetics, Harokopio University, Athens, Greece. 4. School of Medicine, University of Thessaly, Larissa, Greece. 5. Eginition Hospital, Department of Social Medicine Psychiatry and Neurology, National and Kapodistrian University of Athens, Athens, Greece. 6. Taub Institute for Research in Alzheimer's Disease and the Aging Brain the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.
Abstract
Background: Subjective cognitive decline (SCD) refers to self-evaluations of impairment in cognitive functions in the absence of objective deficits. Frailty is a multidimensional syndrome that results in increased vulnerability. Both terms are associated with cognitive decline and increased incidence of dementia. The aim of this study was to explore potential associations between SCD and frailty in elderly individuals. Methods: In this cross-sectional study, we included 1454 participants aged 65 and older from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study. Individuals with a diagnosis of dementia, mild cognitive impairment, severe anxiety or depression were excluded. SCD were assessed with eighteen questions categorized into cognitive domains. Frailty was assessed according to the Fried definition, the Frailty Index (FI) and the Tilburg Frailty Indicator (TFI). Logistic regression analysis was used to investigate the association. Results: Lower educational level, female sex and low socioeconomic status were found to be associated with frailty and more SCD complaints. Having two or more types of SCD complaints was significantly associated with frailty according to all frailty definitions. All types of SCD complaints were significantly associated with the FI and the TFI. In addition, SCD complaints concerning problems requiring mathematical reasoning had the strongest association with frailty. Conclusion: We found that SCD complaints may be a valid indicator of frailty in cognitively unimpaired older people. We believe that SCD may provide a crucial proactive assessment to detect frailty and to implement programs that will help maintain good health and quality of life during aging.
Background: Subjective cognitive decline (SCD) refers to self-evaluations of impairment in cognitive functions in the absence of objective deficits. Frailty is a multidimensional syndrome that results in increased vulnerability. Both terms are associated with cognitive decline and increased incidence of dementia. The aim of this study was to explore potential associations between SCD and frailty in elderly individuals. Methods: In this cross-sectional study, we included 1454 participants aged 65 and older from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study. Individuals with a diagnosis of dementia, mild cognitive impairment, severe anxiety or depression were excluded. SCD were assessed with eighteen questions categorized into cognitive domains. Frailty was assessed according to the Fried definition, the Frailty Index (FI) and the Tilburg Frailty Indicator (TFI). Logistic regression analysis was used to investigate the association. Results: Lower educational level, female sex and low socioeconomic status were found to be associated with frailty and more SCD complaints. Having two or more types of SCD complaints was significantly associated with frailty according to all frailty definitions. All types of SCD complaints were significantly associated with the FI and the TFI. In addition, SCD complaints concerning problems requiring mathematical reasoning had the strongest association with frailty. Conclusion: We found that SCD complaints may be a valid indicator of frailty in cognitively unimpaired older people. We believe that SCD may provide a crucial proactive assessment to detect frailty and to implement programs that will help maintain good health and quality of life during aging.
Authors: Ece Kocagoncu; David Nesbitt; Tina Emery; Laura E Hughes; Richard N Henson; James B Rowe Journal: J Neurosci Date: 2022-01-10 Impact factor: 6.709
Authors: Jong Bin Bae; Darren M Lipnicki; Ji Won Han; Perminder S Sachdev; Tae Hui Kim; Kyung Phil Kwak; Bong Jo Kim; Shin Gyeom Kim; Jeong Lan Kim; Seok Woo Moon; Joon Hyuk Park; Seung-Ho Ryu; Jong Chul Youn; Dong Young Lee; Dong Woo Lee; Seok Bum Lee; Jung Jae Lee; Jin Hyeong Jhoo; Juan J Llibre-Rodriguez; Jorge J Llibre-Guerra; Adolfo J Valhuerdi-Cepero; Karen Ritchie; Marie-Laure Ancelin; Isabelle Carriere; Ingmar Skoog; Jenna Najar; Therese Rydberg Sterner; Nikolaos Scarmeas; Mary Yannakoulia; Efthimios Dardiotis; Kenichi Meguro; Mari Kasai; Kei Nakamura; Steffi Riedel-Heller; Susanne Roehr; Alexander Pabst; Martin van Boxtel; Sebastian Köhler; Ding Ding; Qianhua Zhao; Xiaoniu Liang; Marcia Scazufca; Antonio Lobo; Concepción De-la-Cámara; Elena Lobo; Ki Woong Kim Journal: BMC Med Date: 2020-08-05 Impact factor: 8.775