OBJECTIVE: Neurostimulation technologies are important for studying neural circuits and the connections that underlie neurological and psychiatric disorders. However, current methods come with limitations such as the restraint on movement imposed by the wires delivering stimulation. The objective of this study was to assess whether the e-Particle (EP), a novel wireless neurostimulator, could sufficiently stimulate the brain to modify behavior without these limitations. APPROACH: Rats were implanted with the EP and a commercially available stimulating electrode. Animals received rewarding brain stimulation, and performance in a conditioned place preference (CPP) task was measured. To ensure stimulation-induced neuronal activation, immediate early gene c-fos expression was also measured. MAIN RESULTS: The EP was validated in a commonly used CPP task by demonstrating that (1) wireless stimulation via the EP induced preference behavior that was comparable to that induced by standard wired electrodes and (2) neuronal activation was observed in projection targets of the stimulation site. SIGNIFICANCE: The EP may help achieve a better understanding of existing brain stimulation methods while overcoming their limitations. Validation of the EP in a behavioral model suggests that the benefits of this technology may extend to other areas of animal research and potentially to human clinical applications.
OBJECTIVE: Neurostimulation technologies are important for studying neural circuits and the connections that underlie neurological and psychiatric disorders. However, current methods come with limitations such as the restraint on movement imposed by the wires delivering stimulation. The objective of this study was to assess whether the e-Particle (EP), a novel wireless neurostimulator, could sufficiently stimulate the brain to modify behavior without these limitations. APPROACH: Rats were implanted with the EP and a commercially available stimulating electrode. Animals received rewarding brain stimulation, and performance in a conditioned place preference (CPP) task was measured. To ensure stimulation-induced neuronal activation, immediate early gene c-fos expression was also measured. MAIN RESULTS: The EP was validated in a commonly used CPP task by demonstrating that (1) wireless stimulation via the EP induced preference behavior that was comparable to that induced by standard wired electrodes and (2) neuronal activation was observed in projection targets of the stimulation site. SIGNIFICANCE: The EP may help achieve a better understanding of existing brain stimulation methods while overcoming their limitations. Validation of the EP in a behavioral model suggests that the benefits of this technology may extend to other areas of animal research and potentially to human clinical applications.
Authors: Kate L Montgomery; Alexander J Yeh; John S Ho; Vivien Tsao; Shrivats Mohan Iyer; Logan Grosenick; Emily A Ferenczi; Yuji Tanabe; Karl Deisseroth; Scott L Delp; Ada S Y Poon Journal: Nat Methods Date: 2015-08-17 Impact factor: 28.547
Authors: Daniel K Freeman; Jonathan M O'Brien; Parshant Kumar; Brian Daniels; Reed A Irion; Louis Shraytah; Brett K Ingersoll; Andrew P Magyar; Andrew Czarnecki; Jesse Wheeler; Jonathan R Coppeta; Michael P Abban; Ronald Gatzke; Shelley I Fried; Seung Woo Lee; Amy E Duwel; Jonathan J Bernstein; Alik S Widge; Ana Hernandez-Reynoso; Aswini Kanneganti; Mario I Romero-Ortega; Stuart F Cogan Journal: Front Neurosci Date: 2017-11-27 Impact factor: 4.677
Authors: Amanda Singer; Shayok Dutta; Eric Lewis; Ziying Chen; Joshua C Chen; Nishant Verma; Benjamin Avants; Ariel K Feldman; John O'Malley; Michael Beierlein; Caleb Kemere; Jacob T Robinson Journal: Neuron Date: 2020-06-08 Impact factor: 17.173