[THE ROLE OF TRANSFORMING GROWTH FACTOR BETA 1 UNDER DISEASES OF LIVER].

The review present analysis of publications considering role of transforming growth factor beta 1 (TGF-β1) under various diseases of liver. The analysis was applied to 46 published articles more than a half of which were published in last five years. Under diseases of liver, TGF-β1 plays a key role both in development of fibrosis and in maintenance of immune homeostasis. The chronic damage of liver results in activation of liver stellated cells and intensification of their production of various cytokines, including TGF-β1 that stimulates stellated cells and hepatocytes acquiring characteristics of miofibroblasts and producing proteins of extracellular matrix that results in development of fibrosis. TGF-β1 also has anti-inflammatory and immune suppressive characteristics manifested in suppression of differentiation of Th cells type I and II thereby controlling inflammatory processes. The clinical data of role of TGF-β1 under various diseases of liver in many ways are contradictory that probably related to its dosage-dependent pleiotropic effect. The value of level of TGF-β1шт blood can reflect complicated balance between fibrinogen and immune suppressive effects of cytokine. The detection of content of cytokine in blood can have diagnostic and prognostic significance in evaluation of condition of liver.