BACKGROUND: The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear. METHODS: Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. The cohort was divided into four groups based on number of lymph nodes (LNs) examined on pathology: 0, 1-8, 9-17, and ≥18 LNs. RESULTS: The rate of occult nodal metastasis was 9.0%. Number of LNs removed was not associated with survival (Reference, 0 LNs; HR = 0.98, 95% CI 0.73-1.32 for 1-8 LNs; HR = 1.22, 95% CI 0.80-1.88 for 9-17 LNs; HR = 0.94, 95% CI 0.61-1.46 for ≥18 LNs) after adjusting for important covariates. CONCLUSIONS: LN sampling is not associated with survival in cN0 major salivary gland ACC.
BACKGROUND: The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear. METHODS: Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. The cohort was divided into four groups based on number of lymph nodes (LNs) examined on pathology: 0, 1-8, 9-17, and ≥18 LNs. RESULTS: The rate of occult nodal metastasis was 9.0%. Number of LNs removed was not associated with survival (Reference, 0 LNs; HR = 0.98, 95% CI 0.73-1.32 for 1-8 LNs; HR = 1.22, 95% CI 0.80-1.88 for 9-17 LNs; HR = 0.94, 95% CI 0.61-1.46 for ≥18 LNs) after adjusting for important covariates. CONCLUSIONS: LN sampling is not associated with survival in cN0 major salivary gland ACC.
Authors: Mihir K Bhayani; Murat Yener; Adel El-Naggar; Adam Garden; Ehab Y Hanna; Randal S Weber; Michael E Kupferman Journal: Cancer Date: 2011-10-21 Impact factor: 6.860
Authors: Michael P Herman; John W Werning; Christopher G Morris; Jessica M Kirwan; Robert J Amdur; William M Mendenhall Journal: Am J Otolaryngol Date: 2013-01-14 Impact factor: 1.808
Authors: R Alex Harbison; Alan J Gray; Ted Westling; Marco Carone; Cristina P Rodriguez; Neal D Futran; Richard B Cannon; Jeffrey Houlton Journal: Laryngoscope Date: 2019-08-29 Impact factor: 3.325