| Literature DB >> 3062001 |
Abstract
The outer membrane of Gram-negative bacteria serves as barrier to permeation. Transport across this barrier often occurs through channels created by porins. Changes in these porins can account for antibiotic resistance. The combination of a permeability barrier and beta-lactamases in the periplasmic space leads to a situation in which concentrations, at the target, of even third-generation cephalosporins, can be significantly decreased.Entities:
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Year: 1988 PMID: 3062001 DOI: 10.1093/jac/22.supplement_a.17
Source DB: PubMed Journal: J Antimicrob Chemother ISSN: 0305-7453 Impact factor: 5.790