| Literature DB >> 30618289 |
Hui Chen1,2, Kun Du1,2, Yan-Jun Sun1,2, Zhi-You Hao1,2, Yan-Li Zhang1,2, Jiang Bai3, Qing-Hua Wang3, Hai-Yu Hu3, Wei-Sheng Feng1,2.
Abstract
A new hydroanthraquinone dimer derivative, solanrubiellin A, was isolated from the whole plants of Solanum lyratum. The structure of 1 was established through extensive NMR spectroscopy analysis, and the absolute configuration was elucidated by comparison of its experimental and calculated ECD spectra. Compound 1 showed antibacterial activity with MIC values of 2-10 µM against several Gram-positive bacteria. Compound 1 also demonstrated cytotoxic activity against human A549, HT-29 and HL-60 cell lines with IC50 values ranging from 2.06 to 9.35 µM.Entities:
Keywords: Solanrubiellin A; Solanum lyratum; antibacterial activity; cytotoxic activity; hydroanthraquinone dimer
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Year: 2019 PMID： 30618289 DOI： 10.1080/14786419.2018.1553173
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861