Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720.

Two new compounds, 5-[2-hydroxypropane-1-yl]-2,6-dimethlbenzene-1,3-diol (1) and coniochaetone L (2), together with 19 known compounds (3-21), were isolated from a deep-sea fungus, Penicillium sp. SCSIO 06720. Their structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism spectra. All the isolated compounds (1-21) were tested for their antibacterial and HIV latency-reversal activities. Among these compounds, compound 16 showed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Methicillin-Resistant Staphylococcus Aureus-shh-1 with MIC values of 10.4 ± 3.7 μg/mL and 46.9 ± 29.7 μg/mL, respectively, which were comparable to that of the positive control ampicillin with MIC values of 0.5 ± 0.4 μg/mL and 2.7 ± 0.9 μg/mL, respectively.