Literature DB >> 30617987

A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.

Kevin B Chiu1,2, Kim M Lee1,3,4, Katelyn N Robillard1,5, Andrew G MacLean6,7,8,9.   

Abstract

With a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. Using the unique archive at the Tulane National Primate Research Center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. This method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner.

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Keywords:  Aging; Astrocyte; Eugeric; Microglia; Neurodegeneration; Neuroinflammation

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Year:  2019        PMID: 30617987      PMCID: PMC6428051          DOI: 10.1007/978-1-4939-9068-9_19

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  2 in total

1.  Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys.

Authors:  Veronica Go; Bethany G E Bowley; Monica A Pessina; Zheng Gang Zhang; Michael Chopp; Seth P Finklestein; Douglas L Rosene; Maria Medalla; Benjamin Buller; Tara L Moore
Journal:  Geroscience       Date:  2019-11-06       Impact factor: 7.713

2.  Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus.

Authors:  Nuria García-Magro; Yasmina B Martin; Alejandra Palomino-Antolin; Javier Egea; Pilar Negredo; Carlos Avendaño
Journal:  Front Neuroanat       Date:  2020-01-22       Impact factor: 3.856

  2 in total

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