Soa-Min Hsu1, Wen-Hung Kuo2, Fang-Chuan Kuo3, Yin-Yin Liao4. 1. Department of Radiology, Kuang Tien General Hospital, Taichung, Taiwan. 2. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. 3. Department of Physical Therapy, Hungkuang University, Taichung, Taiwan. 4. Department of Biomedical Engineering, Hungkuang University, 1018, Section 6, Taiwan Boulevard Road, Taichung, 43302, Taiwan, ROC. g9612536@gmail.com.
Abstract
RATIONALE AND OBJECTIVES: The ultrasound B-mode-based morphological and texture analysis and Nakagami parametric imaging have been proposed to characterize breast tumors. Since these three feature categories of ultrasonic tissue characterization supply information on different physical characteristics of breast tumors, by combining the above methods is expected to provide more clues for classifying breast tumors. MATERIALS AND METHODS: To verify the validity of the concept, raw data were obtained from 160 clinical cases. Six different types of morphological-feature parameters, four texture features, and the Nakagami parameter of benignancy and malignancy were extracted for evaluation. The Pearson's correlation matrix was used to calculate the correlation between different feature parameters. The fuzzy c-means clustering and stepwise regression techniques were utilized to determine the optimal feature set, respectively. The logistic regression, receiver operating characteristic curve, and support vector machine were used to estimate the diagnostic ability. RESULTS: The best performance was obtained by combining morphological-feature parameter (e.g., standard deviation of the shortest distance), texture feature (e.g., variance), and the Nakagami parameter, with an accuracy of 89.4%, a specificity of 86.3%, a sensitivity of 92.5%, and an area under receiver operating characteristic curve of 0.96. There was no significant difference between using fuzzy c-means clustering, logistic regression, and support vector machine based on the optimal feature set for breast tumors classification. CONCLUSION: Therefore, we verified that different physical ultrasonic features are functionally complementary and thus improve the performance in diagnosing breast tumors. Moreover, the optimal feature set had the maximum discriminating performance should be irrelative to the power of classifiers.
RATIONALE AND OBJECTIVES: The ultrasound B-mode-based morphological and texture analysis and Nakagami parametric imaging have been proposed to characterize breast tumors. Since these three feature categories of ultrasonic tissue characterization supply information on different physical characteristics of breast tumors, by combining the above methods is expected to provide more clues for classifying breast tumors. MATERIALS AND METHODS: To verify the validity of the concept, raw data were obtained from 160 clinical cases. Six different types of morphological-feature parameters, four texture features, and the Nakagami parameter of benignancy and malignancy were extracted for evaluation. The Pearson's correlation matrix was used to calculate the correlation between different feature parameters. The fuzzy c-means clustering and stepwise regression techniques were utilized to determine the optimal feature set, respectively. The logistic regression, receiver operating characteristic curve, and support vector machine were used to estimate the diagnostic ability. RESULTS: The best performance was obtained by combining morphological-feature parameter (e.g., standard deviation of the shortest distance), texture feature (e.g., variance), and the Nakagami parameter, with an accuracy of 89.4%, a specificity of 86.3%, a sensitivity of 92.5%, and an area under receiver operating characteristic curve of 0.96. There was no significant difference between using fuzzy c-means clustering, logistic regression, and support vector machine based on the optimal feature set for breast tumors classification. CONCLUSION: Therefore, we verified that different physical ultrasonic features are functionally complementary and thus improve the performance in diagnosing breast tumors. Moreover, the optimal feature set had the maximum discriminating performance should be irrelative to the power of classifiers.
Entities:
Keywords:
Breast ultrasound; Classification; Morphological features; Nakagami parameter; Texture features
Authors: Saedeh Zamani; Mehdi Shafeie-Ardestani; Ahmad Bitarafan-Rajabi; Ali Khalaj; Omid Sabzevari Journal: IET Nanobiotechnol Date: 2020-09 Impact factor: 1.847