U Hidding1, A Gulberti2, C Pflug3, C Choe1, A Horn1, L Prilop1, H Braaß1, O Fründt1, C Buhmann1, D Weiss4, M Westphal5, A K Engel6, C Gerloff1, J A Köppen5, W Hamel5, C K E Moll6, M Pötter-Nerger7. 1. Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. 2. Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany; Department of Neurophysiology and Pathophysiology, Institute of Experimental medicine, 20246, Hamburg, Germany. 3. Department of Voice, Speech and Hearing Disorders, Center for Clinical Neurosciences, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. 4. Centre of Neurology, Department for Neurodegenerative Diseases and Hertie- Institute for Clinical Brain Research, 72076, Tübingen, Germany. 5. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. 6. Department of Neurophysiology and Pathophysiology, Institute of Experimental medicine, 20246, Hamburg, Germany. 7. Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. Electronic address: m.poetter-nerger@uke.de.
Abstract
OBJECTIVE: To compare the effect of simultaneous deep brain stimulation of the subthalamic nucleus and substantia nigra pars reticulata (STN+SNr-DBS) to conventional subthalamic stimulation (STN-DBS) on sleep quality in Parkinson's disease (PD) patients. METHODS: The study was a single-center, randomized, double-blind, cross-over clinical trial to compare the effect of STN-DBS vs. combined STN+SNr-DBS on subjective measures of sleep quality. Fifteen PD patients (2 female, age 62.5 ± 6.7 years) suffering from moderate idiopathic PD (disease duration: 12.0 ± 5.0 years, Hoehn & Yahr stage: 2.2 ± 0.4 in the MED-ON & STN-DBS-ON condition, Hoehn & Yahr stage: 2.6 ± 0.8 in the MED-OFF condition preoperatively) participated in the study. Sleep quality was evaluated in both stimulation conditions using the PDSS-2 score as a self-rating questionnaire covering several aspects of sleep disturbances. RESULTS: PD patients showed mild-moderate sleep disturbances (STN-DBS: PDSS-2 score 17.0 ± 11.0; STN+SNr-DBS: 14.7 ± 9.5) with slight but not significant differences between both stimulation conditions. Considering the different subitems of the PDSS-2, combined STN+SNr stimulation was superior to conventional STN stimulation in improving restless legs symptoms (RLS) at night (STN-DBS = 1.9 ± 2.7 STN+SNr-DBS = 1.0 ± 1.8; W = -2.06, p = 0.039) and immobility at night (STN-DBS = 1.5 ± 1.4 STN+SNr-DBS = 0.6 ± 0.8; W = -2.041, p = 0.041). CONCLUSION: This study demonstrates the safety of STN+SNr-DBS compared to conventional STN-DBS on sleep in general with potential beneficial input on RLS symptoms and akinesia at night.
RCT Entities:
OBJECTIVE: To compare the effect of simultaneous deep brain stimulation of the subthalamic nucleus and substantia nigra pars reticulata (STN+SNr-DBS) to conventional subthalamic stimulation (STN-DBS) on sleep quality in Parkinson's disease (PD) patients. METHODS: The study was a single-center, randomized, double-blind, cross-over clinical trial to compare the effect of STN-DBS vs. combined STN+SNr-DBS on subjective measures of sleep quality. Fifteen PDpatients (2 female, age 62.5 ± 6.7 years) suffering from moderate idiopathic PD (disease duration: 12.0 ± 5.0 years, Hoehn & Yahr stage: 2.2 ± 0.4 in the MED-ON & STN-DBS-ON condition, Hoehn & Yahr stage: 2.6 ± 0.8 in the MED-OFF condition preoperatively) participated in the study. Sleep quality was evaluated in both stimulation conditions using the PDSS-2 score as a self-rating questionnaire covering several aspects of sleep disturbances. RESULTS:PDpatients showed mild-moderate sleep disturbances (STN-DBS: PDSS-2 score 17.0 ± 11.0; STN+SNr-DBS: 14.7 ± 9.5) with slight but not significant differences between both stimulation conditions. Considering the different subitems of the PDSS-2, combined STN+SNr stimulation was superior to conventional STN stimulation in improving restless legs symptoms (RLS) at night (STN-DBS = 1.9 ± 2.7 STN+SNr-DBS = 1.0 ± 1.8; W = -2.06, p = 0.039) and immobility at night (STN-DBS = 1.5 ± 1.4 STN+SNr-DBS = 0.6 ± 0.8; W = -2.041, p = 0.041). CONCLUSION: This study demonstrates the safety of STN+SNr-DBS compared to conventional STN-DBS on sleep in general with potential beneficial input on RLS symptoms and akinesia at night.
Authors: Marta Villadóniga; Lidia Cabañes-Martínez; Laura López-Viñas; Samira Fanjul; Marta Del Álamo; Ignacio Regidor Journal: J Clin Med Date: 2022-04-18 Impact factor: 4.964
Authors: Martin A Horn; Alessandro Gulberti; Ute Hidding; Christian Gerloff; Wolfgang Hamel; Christian K E Moll; Monika Pötter-Nerger Journal: Front Hum Neurosci Date: 2022-01-12 Impact factor: 3.169
Authors: Jonas R Wagner; Miriam Schaper; Wolfgang Hamel; Manfred Westphal; Christian Gerloff; Andreas K Engel; Christian K E Moll; Alessandro Gulberti; Monika Pötter-Nerger Journal: Front Hum Neurosci Date: 2022-02-28 Impact factor: 3.169