Literature DB >> 30616165

Ratiometric fluorescent probe based on pyrrole-modified rhodamine 6G hydrazone for the imaging of Cu2+ in lysosomes.

Wei-Na Wu1, Hao Wu1, Run-Bin Zhong1, Yuan Wang2, Zhi-Hong Xu3, Xiao-Lei Zhao1, Zhou-Qing Xu4, Yun-Chang Fan1.   

Abstract

A novel rhodamine-based Schiff base derivative was obtained via the simple condensation of substituted formyl-1H-pyrrole and rhodamine 6G hydrazone. Fluorescence resonance energy transfer enabled the subsequent use of the derivative as a naked-eye colorimetric and ratiometric fluorescent sensor for Cu2+ in semi-aqueous solution, and the existence of the morpholine group enabled the further application of the sensor in imaging Cu2+ in the lysosomes of HeLa cells.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cu(2+); FRET; Lysosome-targeting; Pyrrole; Ratiometric fluorescent probe; Rhodamine hydrazone

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Year:  2018        PMID: 30616165     DOI: 10.1016/j.saa.2018.12.041

Source DB:  PubMed          Journal:  Spectrochim Acta A Mol Biomol Spectrosc        ISSN: 1386-1425            Impact factor:   4.098


  1 in total

Review 1.  Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes.

Authors:  Huimin Chen; Zhenjie Yu; Shiwei Ren; Yuyu Qiu
Journal:  Front Pharmacol       Date:  2022-07-19       Impact factor: 5.988

  1 in total

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