Feng Tian1, Qun-Yan Xiang1, Ming-Yu Zhang2, Yan-Qiao Chen1, Qiu-Zhen Lin1, Tie Wen3, Ling Liu4. 1. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South, PR China; Research Institute of Blood Lipid and Atherosclerosis, The Second Xiangya Hospital, Central South, PR China. 2. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South, PR China; Research Institute of Blood Lipid and Atherosclerosis, The Second Xiangya Hospital, Central South, PR China; Department of Cardiovascular Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, PR China. 3. Department of Emergency, The Second Xiangya Hospital, Central South, PR China. 4. Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South, PR China; Research Institute of Blood Lipid and Atherosclerosis, The Second Xiangya Hospital, Central South, PR China. Electronic address: feliuling@csu.edu.cn.
Abstract
BACKGROUND: Overweight is always accompanied by hypertriglyceridemia (HTG), but the change in non-fasting triglyceride (TG) concentration in overweight subjects without postprandial hypertriglyceridemia was unknown. METHODS: Concentrations of serum lipids were measured at 2 and 4 h in matched overweight (OW group, n = 54) and control subjects (CON group, n = 55) after a daily meal. Concentrations of remnant cholesterol and non-HDL cholesterol were calculated according to the formulas. The diagnostic criteria for non-fasting HTG were based on 2 different consensus statement. ROC curve was used to determine the pointcut of postprandial HTG. RESULTS: OW group had higher fasting concentrations of RC and non-HDL-C than CON group. Non-fasting concentrations of triglyceride and RC significantly increased in 2 groups while were higher in OW group (p < .05). The proportion of non-fasting HTG increased after a daily meal in OW group was significantly higher than the percentage of fasting HTG (p < .05). There was a significant correlation between the postprandial concentrations of TG and RC. CONCLUSIONS: Overweight subjects were more likely to develop non-fasting hypertriglyceridemia and higher concentrations of RC and non-HDL-C. Additionally, 2.0 mmol/l at 4 h after breakfast could be a pointcut value to detect changes in lipid profile of Chinese overweight people.
BACKGROUND: Overweight is always accompanied by hypertriglyceridemia (HTG), but the change in non-fasting triglyceride (TG) concentration in overweight subjects without postprandial hypertriglyceridemia was unknown. METHODS: Concentrations of serum lipids were measured at 2 and 4 h in matched overweight (OW group, n = 54) and control subjects (CON group, n = 55) after a daily meal. Concentrations of remnant cholesterol and non-HDL cholesterol were calculated according to the formulas. The diagnostic criteria for non-fasting HTG were based on 2 different consensus statement. ROC curve was used to determine the pointcut of postprandial HTG. RESULTS: OW group had higher fasting concentrations of RC and non-HDL-C than CON group. Non-fasting concentrations of triglyceride and RC significantly increased in 2 groups while were higher in OW group (p < .05). The proportion of non-fasting HTG increased after a daily meal in OW group was significantly higher than the percentage of fasting HTG (p < .05). There was a significant correlation between the postprandial concentrations of TG and RC. CONCLUSIONS: Overweight subjects were more likely to develop non-fasting hypertriglyceridemia and higher concentrations of RC and non-HDL-C. Additionally, 2.0 mmol/l at 4 h after breakfast could be a pointcut value to detect changes in lipid profile of Chinese overweight people.
Authors: Li-Ling Guo; Yan-Qiao Chen; Qiu-Zhen Lin; Feng Tian; Qun-Yan Xiang; Li-Yuan Zhu; Jin Xu; Tie Wen; Ling Liu Journal: Front Cardiovasc Med Date: 2021-04-01
Authors: Yangrong Tan; Qiuzhen Lin; Jin Xu; Liyuan Zhu; Liling Guo; Yingying Xie; Xiao Du; Shilan Zhang; Tie Wen; Ling Liu Journal: Front Cardiovasc Med Date: 2022-04-12