Literature DB >> 3061529

Adult T-cell leukemia.

T Uchiyama1.   

Abstract

Adult T-cell leukemia (ATL) is a leukemia caused by a monoclonal expansion of HTLV-I-infected T-cells expressing a CD4 antigen. The clinical features of ATL include lymphadenopathy, hepatosplenomegaly, frequent skin lesions, hypercalcemia and a rapidly fatal course. The cell surface phenotype, cytogenetics and functions of leukemic cells are described in association with various clinical manifestations and HTLV-I infection. Leukemic cells constitutively express the p55 (Tac antigen) subunit of the interleukin-2 (IL-2) receptor. Its association with the function of HTLV-I gene products and its possible role in the leukemogenesis of ATL are discussed. Finally, the potential of some therapeutic agents which may selectively eliminate the Tac-expressing leukemic cells in vitro are described, and these may provide an improvement over currently ineffective combination chemotherapy.

Entities:  

Mesh：

Year:  1988        PMID： 3061529     DOI： 10.1016/0268-960x(88)90012-4

Source DB:  PubMed          Journal:  Blood Rev        ISSN： 0268-960X            Impact factor:   8.250


  8 in total

1.  Spontaneous cell proliferation is associated with poor sensitivity to glucocorticoids in patients infected with HTLV.

Authors:  R P Lopes; M Menna-Barreto; M E Bauer
Journal:  Cell Prolif       Date:  2007-02       Impact factor: 6.831

2.  Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease.

Authors:  Yoshimi Enose-Akahata; Unsong Oh; Christian Grant; Steven Jacobson
Journal:  Blood       Date:  2008-05-28       Impact factor: 22.113

3.  HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infection.

Authors:  Chibueze Chioma Ezinne; Makoto Yoshimitsu; Yohann White; Naomichi Arima
Journal:  PLoS One       Date:  2014-02-05       Impact factor: 3.240

Review 4.  Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP.

Authors:  Yoshimi Enose-Akahata; Ashley Vellucci; Steven Jacobson
Journal:  Front Microbiol       Date:  2017-12-21       Impact factor: 5.640

5.  Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases.

Authors:  Yoshimi Enose-Akahata; Shila Azodi; Bryan R Smith; Bridgette Jeanne Billioux; Ashley Vellucci; Nyater Ngouth; Yuetsu Tanaka; Joan Ohayon; Irene Cortese; Avindra Nath; Steven Jacobson
Journal:  PLoS Pathog       Date:  2018-04-30       Impact factor: 6.823

6.  Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia.

Authors:  J M Moseley; J A Danks; V Grill; T A Lister; M A Horton
Journal:  Br J Cancer       Date:  1991-10       Impact factor: 7.640

7.  The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

Authors:  A Imura; T Hori; K Imada; T Ishikawa; Y Tanaka; M Maeda; S Imamura; T Uchiyama
Journal:  J Exp Med       Date:  1996-05-01       Impact factor: 14.307

Review 8.  Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Authors:  Yoshimi Enose-Akahata; Steven Jacobson
Journal:  Retrovirology       Date:  2019-11-29       Impact factor: 4.602
  8 in total

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