Ivo S Muskens1, Anna H Wu1,2, Jacqueline Porcel1, Iona Cheng3, Loïc Le Marchand4, Joseph L Wiemels1, Veronica Wendy Setiawan1,2. 1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. 2. Norris Comprehensive Cancer Center, Los Angeles, California. 3. University of California San Francisco, San Francisco, California. 4. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Abstract
BACKGROUND: Meningioma is the most common intracranial tumor in the US and its etiology remains poorly understood. Meningioma has been predominantly studied among white populations. The aim of this study was to evaluate the associations of anthropometric, comorbidity, and hormonal factors with meningioma in an ethnically diverse population. METHODS: A nested case-control analysis was performed within the Multiethnic Cohort (MEC). Meningioma cases were identified via linkage with Medicare and the California Office of Statewide Health Planning and Development Hospital Discharge data and were matched to up to 10 controls. Anthropometric, comorbidities, physical activity level, and hormonal factors at baseline based on questionnaires were evaluated for association with meningioma. RESULTS: A total of 894 cases and 8918 matched controls were included in this study. Increasing body mass index (BMI) (P-trend = 0.041) and weight increases since age 21 (P-trend = 0.0052) were positively associated with meningioma. Hormonal factors including oral contraceptive use (odds ratio [OR]: 1.24; 95% CI: 1.01-1.51) and estrogen hormonal therapy use (per 5 years, OR: 1.07; 95% CI: 1.01-1.15) were associated with meningioma risk. Hypertension was positively associated with meningioma (OR: 1.26; 95% CI: 1.09-1.47), with individuals who reported a history of both hypertension and diabetes showing a stronger association (OR: 1.54; 95% CI: 1.17-2.03). The tests for heterogeneity across race/ethnicity were not statistically significant (P heterogeneity ≥ 0.17); however, the association of BMI with meningioma was mainly observed in Japanese Americans (P-trend = 0.0036) and hypertension in Japanese Americans (OR: 1.63; 95% CI: 1.17-2.27) and Native Hawaiians (OR: 1.86; 95% CI: 1.02-3.40). CONCLUSION: Obesity, hormonal factors, and hypertension were associated with meningioma in an ethnically diverse population.
BACKGROUND:Meningioma is the most common intracranial tumor in the US and its etiology remains poorly understood. Meningioma has been predominantly studied among white populations. The aim of this study was to evaluate the associations of anthropometric, comorbidity, and hormonal factors with meningioma in an ethnically diverse population. METHODS: A nested case-control analysis was performed within the Multiethnic Cohort (MEC). Meningioma cases were identified via linkage with Medicare and the California Office of Statewide Health Planning and Development Hospital Discharge data and were matched to up to 10 controls. Anthropometric, comorbidities, physical activity level, and hormonal factors at baseline based on questionnaires were evaluated for association with meningioma. RESULTS: A total of 894 cases and 8918 matched controls were included in this study. Increasing body mass index (BMI) (P-trend = 0.041) and weight increases since age 21 (P-trend = 0.0052) were positively associated with meningioma. Hormonal factors including oral contraceptive use (odds ratio [OR]: 1.24; 95% CI: 1.01-1.51) and estrogen hormonal therapy use (per 5 years, OR: 1.07; 95% CI: 1.01-1.15) were associated with meningioma risk. Hypertension was positively associated with meningioma (OR: 1.26; 95% CI: 1.09-1.47), with individuals who reported a history of both hypertension and diabetes showing a stronger association (OR: 1.54; 95% CI: 1.17-2.03). The tests for heterogeneity across race/ethnicity were not statistically significant (P heterogeneity ≥ 0.17); however, the association of BMI with meningioma was mainly observed in Japanese Americans (P-trend = 0.0036) and hypertension in Japanese Americans (OR: 1.63; 95% CI: 1.17-2.27) and Native Hawaiians (OR: 1.86; 95% CI: 1.02-3.40). CONCLUSION: Obesity, hormonal factors, and hypertension were associated with meningioma in an ethnically diverse population.
Authors: Dominique S Michaud; Valentina Gallo; Brigitte Schlehofer; Anne Tjønneland; Anja Olsen; Kim Overvad; Christina C Dahm; Rudolf Kaaks; Annekatrin Lukanova; Heiner Boeing; Madlen Schütze; Antonia Trichopoulou; Christina Bamia; Andreas Kyrozis; Carlotta Sacerdote; Claudia Agnoli; Domenico Palli; Rosario Tumino; Amalia Mattiello; H Bas Bueno-de-Mesquita; Martine M Ros; Petra H M Peeters; Carla H van Gils; Eiliv Lund; Kjersti Bakken; Inger T Gram; Aurelio Barricarte; Carmen Navarro; Miren Dorronsoro; Maria José Sánchez; Laudina Rodríguez; Eric J Duell; Göran Hallmans; Beatrice S Melin; Jonas Manjer; Signe Borgquist; Kay-Tee Khaw; Nick Wareham; Naomi E Allen; Konstantinos K Tsilidis; Isabelle Romieu; Sabina Rinaldi; Paolo Vineis; Elio Riboli Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-08-27 Impact factor: 4.254
Authors: Elizabeth B Claus; Lisa Calvocoressi; Melissa L Bondy; Joellen M Schildkraut; Joseph L Wiemels; Margaret Wrensch Journal: Cancer Date: 2012-04-10 Impact factor: 6.860
Authors: Behnam Asgharian; Yuan-Jia Chen; Nicholas J Patronas; Paolo L Peghini; James C Reynolds; Alexander Vortmeyer; Zhengping Zhuang; David J Venzon; Fathia Gibril; Robert T Jensen Journal: Clin Cancer Res Date: 2004-02-01 Impact factor: 12.531
Authors: Melissa Z Braganza; Cari M Kitahara; Amy Berrington de González; Peter D Inskip; Kimberly J Johnson; Preetha Rajaraman Journal: Neuro Oncol Date: 2012-09-05 Impact factor: 12.300
Authors: M Wiedmann; C Brunborg; K Lindemann; T B Johannesen; L Vatten; E Helseth; J A Zwart Journal: Br J Cancer Date: 2013-06-18 Impact factor: 7.640
Authors: Quinn T Ostrom; Maral Adel Fahmideh; David J Cote; Ivo S Muskens; Jeremy M Schraw; Michael E Scheurer; Melissa L Bondy Journal: Neuro Oncol Date: 2019-11-04 Impact factor: 12.300
Authors: Claudine M Samanic; Jamie K Teer; Zachary J Thompson; Jordan H Creed; Sepideh Mokhtari; Brooke L Fridley; L Burt Nabors; Sion L Williams; Kathleen M Egan Journal: J Neurooncol Date: 2021-10-20 Impact factor: 4.130
Authors: Jenny Pettersson-Segerlind; Tiit Mathiesen; Adrian Elmi-Terander; Erik Edström; Mats Talbäck; Maria Feychting; Giorgio Tettamanti Journal: Sci Rep Date: 2021-04-28 Impact factor: 4.379
Authors: Anna H Wu; Jun Wu; Chiuchen Tseng; Juan Yang; Salma Shariff-Marco; Scott Fruin; Timothy Larson; Veronica W Setiawan; Shahir Masri; Jacqueline Porcel; Jennifer Jain; Thomas C Chen; Daniel O Stram; Loïc Le Marchand; Beate Ritz; Iona Cheng Journal: JNCI Cancer Spectr Date: 2020-01-03
Authors: Laura Dresser; Ryan T Merrell; David Olayinka Kamson; Carlen Amy Yuen; Andrew Wilmington; Matthew Walker; Tilley Jenkins Vogel Journal: Sci Rep Date: 2020-10-21 Impact factor: 4.996