Emilie Lardenois1, Laurent Michaud2, Anne Schneider3, Mihaela Onea4, Julie Rebeuh3, Madeleine Gottrand-Aumar2, Florence Renaud1,5, Frederic Gottrand2, Emmanuelle Leteurtre1,5. 1. Institut de Pathologie, CHU Lille. 2. Centre de Référence des Affections Chroniques et Malformatives de l'Œsophage, CHU Lille, Lille Inflammation Research International Center, University Lille, Lille. 3. Service de Chirurgie Pédiatrique, CHU de Strasbourg. 4. Institut de Pathologie, CHU de Strasbourg, Strasbourg. 5. University Lille, Inserm, JPARC-Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.
Abstract
BACKGROUND AND OBJECTIVE: Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients' characteristics. METHODS: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA. A standardized form was used to collect clinical and endoscopic data. Diagnosis of EoE was made as ≥15 intraepithelial eosinophils/high power field, whatever the response on proton pump inhibitors therapy. RESULTS: Six patients (9.5%) presented an EoE (17-100 eosinophils/high power field). An atopic condition was reported more frequently in the eosinophil ≥15 group than in patients with no EoE (66% vs 16%; P = 0.014). Except for chest pain, symptoms and endoscopic features were similar in patients with EoE and patients with no EoE. CONCLUSION: In our series of 63 patients born with EA, mainly distal tracheoesophageal fistula, the prevalence of EoE is increased, and therefore should be considered in adolescents with EA.
BACKGROUND AND OBJECTIVE:Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients' characteristics. METHODS: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA. A standardized form was used to collect clinical and endoscopic data. Diagnosis of EoE was made as ≥15 intraepithelial eosinophils/high power field, whatever the response on proton pump inhibitors therapy. RESULTS: Six patients (9.5%) presented an EoE (17-100 eosinophils/high power field). An atopic condition was reported more frequently in the eosinophil ≥15 group than in patients with no EoE (66% vs 16%; P = 0.014). Except for chest pain, symptoms and endoscopic features were similar in patients with EoE and patients with no EoE. CONCLUSION: In our series of 63 patients born with EA, mainly distal tracheoesophageal fistula, the prevalence of EoE is increased, and therefore should be considered in adolescents with EA.
Authors: Renato Tambucci; Francesca Rea; Giulia Angelino; Monica Malamisura; Maurizio Mennini; Carla Riccardi; Giovanni Farello; Laura Valfré; Luigi Dall'Oglio; Jonathan E Markowitz; Alessandro G Fiocchi; Paola De Angelis Journal: World Allergy Organ J Date: 2020-04-02 Impact factor: 4.084
Authors: Martina Votto; Gian Luigi Marseglia; Maria De Filippo; Ilaria Brambilla; Silvia Maria Elena Caimmi; Amelia Licari Journal: Front Pediatr Date: 2020-05-29 Impact factor: 3.418