Shuying Li1, Yaxing Hou2,3, Xinxin Yan2,3, Yuwen Wang2,3, Chen Shi2,3, Xiaoyan Wu4, Huihuan Liu4, Liwen Zhang2,3, Xumei Zhang3,5, Juan Liu6, Ming Zhang7, Qiang Zhang2,3, Naijun Tang2,3. 1. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. 2. Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China. 3. Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin, China. 4. Beichen District Women's and Children's Health Center, Tianjin, China. 5. Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China. 6. Department of Biomedical Information and Library, Tianjin Medical University, Tianjin, China. 7. Tianjin Centers for Disease Control and Prevention, Tianjin, China.
Abstract
BACKGROUND: This study examined whether folate and vitamin B12 imbalance is associated with gestational diabetes mellitus (GDM) and explored interactions between B vitamin imbalance and maternal risk factors for GDM. METHODS: A cross-sectional study was performed in 406 Chinese pregnant women. Serum folate, vitamin B12 , and blood glucose concentrations were measured at 24 to 28 weeks gestation during GDM screening. A diagnosis of GDM was made based on International Association of Diabetes and Pregnancy Study Groups criteria (fasting plasma glucose [FPG] ≥5.1 mM, 1-hour plasma glucose ≥10.0 mM, or 2-hour plasma glucose ≥8.5 mM). Binary logistic regression was used to obtain odds ratios (ORs) after controlling for different confounders. RESULTS: Higher folate levels were associated with higher glucose concentrations and a higher risk of GDM (OR 1.98; 95% confidence interval [CI] 1.00-3.90), whereas higher vitamin B12 levels were associated with lower FPG and a lower risk of GDM (OR 0.30; 95% CI 0.15-0.60). A higher folate: vitamin B12 ratio was associated with higher glucose and a higher risk of GDM (OR 3.08; 95% CI 1.63-5.83). The presence of both a higher folate: vitamin B12 ratio and advanced age further increased the OR to 2.13 (95% CI 1.09-4.15) with a significant additive interaction. Furthermore, a higher folate: vitamin B12 ratio and a higher prepregnancy body mass index (pp-BMI) were synergistically associated with an increased risk of GDM (OR 3.03; 95% CI 1.40-6.57). CONCLUSIONS: An imbalance between folate and vitamin B12 , represented by a higher folate: vitamin B12 ratio, was highly associated with GDM risk, and this association could be further modified by maternal age and pp-BMI.
BACKGROUND: This study examined whether folate and vitamin B12 imbalance is associated with gestational diabetes mellitus (GDM) and explored interactions between B vitamin imbalance and maternal risk factors for GDM. METHODS: A cross-sectional study was performed in 406 Chinese pregnant women. Serum folate, vitamin B12 , and blood glucose concentrations were measured at 24 to 28 weeks gestation during GDM screening. A diagnosis of GDM was made based on International Association of Diabetes and Pregnancy Study Groups criteria (fasting plasma glucose [FPG] ≥5.1 mM, 1-hour plasma glucose ≥10.0 mM, or 2-hour plasma glucose ≥8.5 mM). Binary logistic regression was used to obtain odds ratios (ORs) after controlling for different confounders. RESULTS: Higher folate levels were associated with higher glucose concentrations and a higher risk of GDM (OR 1.98; 95% confidence interval [CI] 1.00-3.90), whereas higher vitamin B12 levels were associated with lower FPG and a lower risk of GDM (OR 0.30; 95% CI 0.15-0.60). A higher folate: vitamin B12 ratio was associated with higher glucose and a higher risk of GDM (OR 3.08; 95% CI 1.63-5.83). The presence of both a higher folate: vitamin B12 ratio and advanced age further increased the OR to 2.13 (95% CI 1.09-4.15) with a significant additive interaction. Furthermore, a higher folate: vitamin B12 ratio and a higher prepregnancy body mass index (pp-BMI) were synergistically associated with an increased risk of GDM (OR 3.03; 95% CI 1.40-6.57). CONCLUSIONS: An imbalance between folate and vitamin B12 , represented by a higher folate: vitamin B12 ratio, was highly associated with GDM risk, and this association could be further modified by maternal age and pp-BMI.
Authors: Jasmine F Plows; Clare M Reynolds; Mark H Vickers; Philip N Baker; Joanna L Stanley Journal: Curr Diab Rep Date: 2019-08-01 Impact factor: 4.810
Authors: Sara L White; Angela C Flynn; Wenneke van Weelden; Paul T Seed; Elie Antoun; Keith M Godfrey; Negusse T Kitaba; Karen A Lillycrop; Kathryn V Dalrymple; Agata Sobczyńska-Malefora; Rebecca C Painter; Lucilla Poston Journal: J Dev Orig Health Dis Date: 2021-05-11 Impact factor: 3.034
Authors: Gang Cheng; Tingting Sha; Xiao Gao; Qiong He; Xialing Wu; Qianling Tian; Fan Yang; Cai Tang; Xihong Wu; Qunhui Xie; Yan Yan Journal: Int J Environ Res Public Health Date: 2019-11-15 Impact factor: 3.390