Literature DB >> 30614271

Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum.

Jia-Min Feng1,2, Min Li1, Jin-Lian Zhao1,2, Xiao-Na Jia1,2, Ji-Mei Liu1,2, Min Zhang1,2, Ri-Dao Chen1,2, Ke-Bo Xie1,2, Da-Wei Chen1,2, Hai-Bo Yu1, Jun-Gui Dai1,2.   

Abstract

Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam (4), were isolated from Stachybotrys chartarum CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 1 and 2 showed inhibitory effect towards potassium channel Kv1.3 with IC50 values of 13.4 and 10.9 μM, respectively.

Entities:  

Keywords:  Phenylspirodrimanes derivatives; potassium channel Kv1.3

Mesh：

Substances：

Year:  2019        PMID： 30614271     DOI： 10.1080/10286020.2018.1551372

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  3 in total

1.  Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease.

Authors:  Mahamudul Hasan; Md Mukthar Mia; Shahab Uddin Munna; Md Mowdudul Hasan Talha; Kanon Das
Journal:  Inform Med Unlocked       Date:  2022-03-26

Review 2.  Stachybotrys chartarum-A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance.

Authors:  Sabrin R M Ibrahim; Hani Choudhry; Amer H Asseri; Mahmoud A Elfaky; Shaimaa G A Mohamed; Gamal A Mohamed
Journal:  J Fungi (Basel)       Date:  2022-05-12

3.  In vitro screening of 65 mycotoxins for insecticidal potential.

Authors:  Mieczysława Irena Boguś; Anna Katarzyna Wrońska; Agata Kaczmarek; Martyna Boguś-Sobocińska
Journal:  PLoS One       Date:  2021-03-18       Impact factor: 3.240
  3 in total

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