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Literature DB >> 30614257

The involvement of mitochondrial fission in maintenance of the stemness of bone marrow mesenchymal stem cells.

Xiaorong Feng¹, Wenjing Zhang^1,2, Wen Yin¹, Y James Kang^1,2.

Abstract

IMPACT STATEMENT: How to maintain the stemness of bone marrow mesenchymal stem cells (BMSCs) in cultures is a long-standing question. The present study found that mitochondrial dynamics affects the stemness of BMSCs in cultures and the retaining of mitochondrial fission enhances the stemness of BMSCs. This work thus provides a novel insight into strategic approaches to maintain the stemness of BMSCs in cultures in relation to the clinical application of bone-marrow stem cells.

Keywords: Bone marrow mesenchymal stem cells; DLP1; maintenance; mitochondrial fission; stemness; tyrphostin A9

Mesh：

Substances：

Year: 2019 PMID： 30614257 PMCID： PMC6362528 DOI： 10.1177/1535370218821063

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

41 in total

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8. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.

Authors: Karoliina Pelttari; Anja Winter; Eric Steck; Katrin Goetzke; Thea Hennig; Bjoern Gunnar Ochs; Thomas Aigner; Wiltrud Richter
Journal: Arthritis Rheum Date: 2006-10

The involvement of mitochondrial fission in maintenance of the stemness of bone marrow mesenchymal stem cells.

Review 1. Mesenchymal stem cells: clinical applications and biological characterization.

2. The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells.

3. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

Review 4. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century.

5. Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.

6. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

7. Multilineage potential of adult human mesenchymal stem cells.

8. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.

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10. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture.

Review 1. Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate.

2. Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone.

3. Mitophagy promotes the stemness of bone marrow-derived mesenchymal stem cells.

Review 4. Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells.