Paul Vanderkam1,2, Clara Blanchard3, Florian Naudet4, Denis Pouchain5, Helene Vaillant Roussel6, Marie Christine Perault-Pochat7, Nematollah Jaafari8, Rémy Boussageon9. 1. Department of General Medicine, University of Poitiers, 6 rue de la Milétrie, TSA 51115, 86073, Poitiers Cedex 9, France. paul.vanderkam@univ-poitiers.fr. 2. Clinical Research Unit, Henri Laborit Hospital, 370 av. Jacques cœur, CS 10587, 86021, Poitiers, France. paul.vanderkam@univ-poitiers.fr. 3. Department of General Medicine, University of Poitiers, 6 rue de la Milétrie, TSA 51115, 86073, Poitiers Cedex 9, France. 4. CHU Rennes, Inserm, CIC 1414 (Clinical Center of Investigation, Rennes), Univ Rennes, F-35000, Rennes, France. 5. Department of General Medicine, University of Tours, 10 boulevard Tonnelé, BP 3223, 37032, Tours Cedex 1, France. 6. Department of General Medicine and UPU ACCePPT, University of Auvergne Clermont-Ferrand Cedex 1, France28 place Henri Dunant, BP 38, 63001, Clermont-Ferrand Cedex 1, France. 7. Clinical Pharmacology and Awareness Department, University Hospital of Poitiers, 2 rue de la Milétrie, BP 577, 86021, Poitiers Cedex, France. 8. CNRS 3557, CIC-P 1402 and Clinical Research Unit, Henri Laborit Hospital, 370 av. Jacques cœur, CS 10587, 86021, Poitiers, France. 9. University College of General Medicine and UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Claude-Bernard Lyon 1 University, CNRS, Lyon, 69622, France.
Abstract
PURPOSE: To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS: Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo. RESULTS: Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness. CONCLUSION: There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.
PURPOSE: To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS: Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo. RESULTS: Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness. CONCLUSION: There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.