José M Ramírez-Moreno1, Pedro Muñoz-Vega2, Sandra Bartolomé Alberca3, Diego Peral-Pacheco4. 1. Extremadura University Medical School, Department of Biomedical Sciences, Badajoz, Spain; Hospital Universitario Infanta Cristina, Stroke Center, Neurology Department, Badajoz, Spain; Multidisciplinary Research Group GRIMEX, Extremadura, Spain. Electronic address: jramrez@unex.es. 2. Hospital de Neurorehabilitación Casaverde, Mérida, Spain. Electronic address: pedromv20@hotmail.com. 3. Hospital Universitario Infanta Cristina, Stroke Center, Neurology Department, Badajoz, Spain. Electronic address: sandrabartolomealberca@gmail.com. 4. Extremadura University Medical School, Department of Medical-Surgery Therapeutics, Badajoz, Spain. Electronic address: diego@unex.es.
Abstract
BACKGROUND: Studies suggest that fatigue and cognitive impairment may be present after transient ischemic attack (TIA) or minor stroke, but little is known about consequences in daily life. The main aim was to explore the presence of fatigue, cognitive impairment, and consequences in daily life after minor stroke-TIA. METHODS: Patients (n = 92) were consecutively recruited from the Stroke Unit and were assessed within 2 weeks of hospital admission for first-ever and 3 months later. Control participants (n = 89) were recruited from the same population as the patients. Measures included the Fatigue Assessment Scale (FAS), Montreal Cognitive Assessment (MoCA), and The European Quality of Life index (EQ-5D-5L). RESULTS: The prevalence of substantial fatigue was 65.2% (confidence interval [CI] 95%: 54.6%-74.8%) and extreme fatigue was 20.7% (CI 95%: 12.9%-30.4%) in minor stroke-TIA patients. The prevalence of substantial fatigue in controls was 23.5% (CI95%: 15.0%-34.0%) and extreme fatigue was 4.5% (CI 95%: 1.8%-11.0%). The mean (SD) score on the MoCA was 24.1 (3.2) for the patients group and 27.3 (2.4) for controls (P < .001). FAS showed the strongest negative correlation score with the EQ-5D-5L index (r = -0.480; P < .0001), higher levels of mental and physical fatigue are associated with lower EQ-5D-5L index (r = -0.376; P < .001 and r = -0.497; P <.001, respectively). The correlations between the FAS and the MoCA measures were no significant. MoCA was not significantly correlated with EQ-5D-5L. CONCLUSIONS: Fatigue was a very common symptom in TIA/minor stroke patients. The fatigue had a significant impact on the health-related quality of life construct in its entirety, even after accounting for the influence of several factors.
BACKGROUND: Studies suggest that fatigue and cognitive impairment may be present after transient ischemic attack (TIA) or minor stroke, but little is known about consequences in daily life. The main aim was to explore the presence of fatigue, cognitive impairment, and consequences in daily life after minor stroke-TIA. METHODS:Patients (n = 92) were consecutively recruited from the Stroke Unit and were assessed within 2 weeks of hospital admission for first-ever and 3 months later. Control participants (n = 89) were recruited from the same population as the patients. Measures included the Fatigue Assessment Scale (FAS), Montreal Cognitive Assessment (MoCA), and The European Quality of Life index (EQ-5D-5L). RESULTS: The prevalence of substantial fatigue was 65.2% (confidence interval [CI] 95%: 54.6%-74.8%) and extreme fatigue was 20.7% (CI 95%: 12.9%-30.4%) in minor stroke-TIApatients. The prevalence of substantial fatigue in controls was 23.5% (CI95%: 15.0%-34.0%) and extreme fatigue was 4.5% (CI 95%: 1.8%-11.0%). The mean (SD) score on the MoCA was 24.1 (3.2) for the patients group and 27.3 (2.4) for controls (P < .001). FAS showed the strongest negative correlation score with the EQ-5D-5L index (r = -0.480; P < .0001), higher levels of mental and physical fatigue are associated with lower EQ-5D-5L index (r = -0.376; P < .001 and r = -0.497; P <.001, respectively). The correlations between the FAS and the MoCA measures were no significant. MoCA was not significantly correlated with EQ-5D-5L. CONCLUSIONS:Fatigue was a very common symptom in TIA/minor strokepatients. The fatigue had a significant impact on the health-related quality of life construct in its entirety, even after accounting for the influence of several factors.
Authors: Mauricio A Ramírez-Moreno; Patricio Carrillo-Tijerina; Milton Osiel Candela-Leal; Myriam Alanis-Espinosa; Juan Carlos Tudón-Martínez; Armando Roman-Flores; Ricardo A Ramírez-Mendoza; Jorge de J Lozoya-Santos Journal: Int J Environ Res Public Health Date: 2021-11-12 Impact factor: 3.390
Authors: Raed A Joundi; Joel Adekanye; Alexander A Leung; Paul Ronksley; Eric E Smith; Alexander D Rebchuk; Thalia S Field; Michael D Hill; Stephen B Wilton; Lauren C Bresee Journal: J Am Heart Assoc Date: 2022-06-22 Impact factor: 6.106
Authors: Neil Heron; Seán R O'Connor; Frank Kee; David R Thompson; Neil Anderson; David Cutting; Margaret E Cupples; Michael Donnelly Journal: Int J Environ Res Public Health Date: 2021-05-02 Impact factor: 3.390