Resistant type II cryoglobulinaemic vasculitis successfully treated with bortezomib in a patient with SLE.

We report an interesting case of hepatitis C virus-negative type II cryoglobulinaemic vasculitis (CV) in a patient with a background history of systemic lupus erythematosus. The type II CV became less responsive to traditional treatments over time and culminated in an intensive care unit admission with critical multiorgan failure. A detailed flow cytometric evaluation of the bone marrow proved to be helpful in treatment. It demonstrated that bortezomib was a viable alternative treatment option for the type II CV. The patient received bortezomib and has made a full and durable recovery. © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.