Marta Kaleta-Richter1, Aleksandra Kawczyk-Krupka2, David Aebisher3, Dorota Bartusik-Aebisher4, Zenon Czuba5, Grzegorz Cieślar6. 1. School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Batorego Street 15, 41-902 Bytom, Poland; School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia in Katowice, Marii Curie - Skłodowskiej Street 10, 41-800 Zabrze, Poland. Electronic address: martakaleta.mk@gmail.com. 2. School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Batorego Street 15, 41-902 Bytom, Poland. Electronic address: akawczyk@sum.edu.pl. 3. Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, Tadeusza Rejtana Avenue 16 C, 35-310 Rzeszów, Poland. Electronic address: daebisher@ur.edu.pl. 4. Department of Biochemistry and General Chemistry, Faculty of Medicine, University of Rzeszów, Tadeusza Rejtana Avenue 16 C, 35-310 Rzeszów, Poland. Electronic address: dbartusik-aebisher@ur.edu.pl. 5. School of Medicine with the Division of Dentistry in Zabrze, Department of Microbiology and Immunology, Medical University of Silesia in Katowice, 19 Jordana St., 41- 808 Zabrze, Poland. Electronic address: zczuba@sum.edu.pl. 6. School of Medicine with the Division of Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Batorego Street 15, 41-902 Bytom, Poland. Electronic address: gcieslar@sum.edu.pl.
Abstract
INTRODUCTION: PDT can interfere with cytokine-mediated responses that play an important role in the processes of cancer progression, tumor angiogenesis and metastasis. Therefore, based on the identification of these cancer biomarkers, the therapy of combining various forms of treatment, including immunotherapy and PDT, may be a justified strategy for colorectal cancer treatment that focuses on individualized comprehensive therapy. METHOD: We reviewed the major approaches on the use of immunotherapy in colorectal cancer, with the special regard to photodynamic therapy, its immunological effect and new oncological treatment directions, connected with adjuvant immunotherapy including use of nanoparticles. Databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. PURPOSE: To review studies of the immunotherapy in colon cancer and immune response to PDT. CONCLUSION: Based on the identification of immunological cancer biomarkers, the therapy of combining various forms of treatment, including immunotherapy and PDT, may be a justified strategy for colorectal cancer treatment that focuses on individualized comprehensive therapy.
INTRODUCTION: PDT can interfere with cytokine-mediated responses that play an important role in the processes of cancer progression, tumor angiogenesis and metastasis. Therefore, based on the identification of these cancer biomarkers, the therapy of combining various forms of treatment, including immunotherapy and PDT, may be a justified strategy for colorectal cancer treatment that focuses on individualized comprehensive therapy. METHOD: We reviewed the major approaches on the use of immunotherapy in colorectal cancer, with the special regard to photodynamic therapy, its immunological effect and new oncological treatment directions, connected with adjuvant immunotherapy including use of nanoparticles. Databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. PURPOSE: To review studies of the immunotherapy in colon cancer and immune response to PDT. CONCLUSION: Based on the identification of immunological cancer biomarkers, the therapy of combining various forms of treatment, including immunotherapy and PDT, may be a justified strategy for colorectal cancer treatment that focuses on individualized comprehensive therapy.
Authors: John A Roque Iii; Houston D Cole; Patrick C Barrett; Liubov M Lifshits; Rachel O Hodges; Susy Kim; Gagan Deep; Antonio Francés-Monerris; Marta E Alberto; Colin G Cameron; Sherri A McFarland Journal: J Am Chem Soc Date: 2022-04-28 Impact factor: 16.383
Authors: Liubov M Lifshits; John A Roque Iii; Prathyusha Konda; Susan Monro; Houston D Cole; David von Dohlen; Susy Kim; Gagan Deep; Randolph P Thummel; Colin G Cameron; Shashi Gujar; Sherri A McFarland Journal: Chem Sci Date: 2020-09-09 Impact factor: 9.825
Authors: Marcin Olek; Agnieszka Machorowska-Pieniążek; Wojciech Stós; Janusz Kalukin; Dorota Bartusik-Aebisher; David Aebisher; Grzegorz Cieślar; Aleksandra Kawczyk-Krupka Journal: Pharmaceutics Date: 2021-05-14 Impact factor: 6.321