| Literature DB >> 30611019 |
Daniela Ávila-González1, Omar Martínez-Alarcón2, Guadalupe García-López2, Néstor Emmanuel Díaz-Martínez3, Guadalupe Razo-Aguilera4, María Yolotzin Valdespino-Vázquez5, Elsa Romelia Moreno-Verduzco6, Eva Vega-Hernández7, Juan Carlos Regalado-Hernández7, Julio Francisco De la Jara-Díaz7, Anayansi Molina-Hernández2, Héctor Flores-Herrera8, Wendy Portillo9, Néstor Fabián Díaz10.
Abstract
Although investigation with human embryonic stem cells (HESC) is not decreasing, the derivation of new lines has been diminished. The preeminence of only a few HESC lines in research is accompanied by lack of universal applicability of results as well as by genetic under-representation. We previously reported the derivation of one line with male karyotype from Mexican population. Here, we derived one HESC line (Amicqui-2) with female karyotype from poor-quality embryos. These line comply the pluripotent requirements (normal karyotype, detection of pluripotency-associated markers, mycoplasma test and teratoma formation) and could be a valuable model for studying diseases specific to under-represented population.Entities:
Mesh:
Year: 2018 PMID: 30611019 DOI: 10.1016/j.scr.2018.101364
Source DB: PubMed Journal: Stem Cell Res ISSN: 1873-5061 Impact factor: 2.020