Literature DB >> 30610415

Stability of Vaccines.

N Dumpa1, K Goel1, Yuhan Guo1, H McFall1, Amit Raviraj Pillai1, Ashay Shukla1, M A Repka1, S Narasimha Murthy2.   

Abstract

Vaccines are considered the most economical and effective preventive measure against most deadly infectious diseases. Vaccines help protect around three million lives every year, but hundreds of thousands of lives are lost due to the instability of vaccines. This review discusses the various types of instability observed, while manufacturing, storing, and distributing vaccines. It describes the specific stability problems associated with each type of vaccine. This review also discusses the various measures adopted to overcome these instability problems. Vaccines are classified based on their components, and this review discusses how these preventive measures relate to each type of vaccine. This review also includes certain case studies that illustrate various approaches to improve vaccine stability. Last, this review provides insight on prospective methods for developing more stable vaccines.

Entities:  

Keywords:  antigen; attenuated; protein; stability; vaccine

Mesh：

Substances：

Year:  2019        PMID： 30610415     DOI： 10.1208/s12249-018-1254-2

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  8 in total

1.  Correlation Study of the Most Important Environmental Influencing Factors on the Razi MMR Vaccine.

Authors:  S Soleimani; S Rashid
Journal:  Arch Razi Inst       Date:  2021-11-30

2.  Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant.

Authors:  Kendall B Preston; Teri Ann S Wong; Albert To; Taylor E Tashiro; Michael M Lieberman; Alex Granados; Karen Feliciano; John Harrison; Jake Yalley-Ogunro; Hanne Andersen Elyard; Oreola Donini; Axel T Lehrer; Theodore W Randolph
Journal:  Vaccine       Date:  2021-08-13       Impact factor: 4.169

Review 3.  A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines.

Authors:  Marek Kloczewiak; Jessica M Banks; Lin Jin; Mark L Brader
Journal:  Mol Pharm       Date:  2022-06-17       Impact factor: 5.364

4.  The impact of sseK2 deletion on Salmonella enterica serovar typhimurium virulence in vivo and in vitro.

Authors:  Xiaojie Zhang; Lei He; Chunjie Zhang; Chuan Yu; Yadong Yang; Yanyan Jia; Xiangchao Cheng; Yinju Li; Chengshui Liao; Jing Li; Zuhua Yu; Fuyu Du
Journal:  BMC Microbiol       Date:  2019-08-07       Impact factor: 3.605

Review 5.  Thermostable Vaccines in Veterinary Medicine: State of the Art and Opportunities to Be Seized.

Authors:  Angela Fanelli; Luca Mantegazza; Saskia Hendrickx; Ilaria Capua
Journal:  Vaccines (Basel)       Date:  2022-02-05

Review 6.  How to accelerate the supply of vaccines to all populations worldwide? Part II: Initial industry lessons learned and detailed technical reflections leveraging the COVID-19 situation.

Authors:  Mic McGoldrick; Thierry Gastineau; Diane Wilkinson; Cristiana Campa; Norbert De Clercq; Andrea Mallia-Milanes; Olivier Germay; Jyothsna Krishnan; M Van Ooij; Michael P Thien; Peter J Mlynarczyk; Edward Saltus; Florence Wauters; Philippe Juvin; Didier Clenet; Ana Basso; Nora Dellepiane; Sonia Pagliusi; Monique Collaço de Moraes Stávale; Venkatraman H Sivaramakrishnan; Samir Desai
Journal:  Vaccine       Date:  2022-02-23       Impact factor: 3.641

7.  Blood transcriptome analysis revealing aging gene expression profiles in red panda.

Authors:  Jing Luo; Liang Zhang; Fujun Shen; Li Luo; Lei Chen; Zhenxin Fan; Rong Hou; Bisong Yue; Xiuyue Zhang
Journal:  PeerJ       Date:  2022-07-22       Impact factor: 3.061

Review 8.  Recombinant vaccines in 2022: a perspective from the cell factory.

Authors:  Marianna Teixeira de Pinho Favaro; Jan Atienza-Garriga; Carlos Martínez-Torró; Eloi Parladé; Esther Vázquez; José Luis Corchero; Neus Ferrer-Miralles; Antonio Villaverde
Journal:  Microb Cell Fact       Date:  2022-10-05       Impact factor: 6.352
  8 in total

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