| Literature DB >> 30610225 |
Antonio Cuadrado1,2, Ana I Rojo1,2, Geoffrey Wells3, John D Hayes4, Sharon P Cousin5, William L Rumsey6, Otis C Attucks7, Stephen Franklin8, Anna-Liisa Levonen9, Thomas W Kensler10, Albena T Dinkova-Kostova11,12.
Abstract
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein homeostasis, as well as the regulation of inflammation. Thus, NRF2 activation provides cytoprotection against numerous pathologies including chronic diseases of the lung and liver; autoimmune, neurodegenerative and metabolic disorders; and cancer initiation. One NRF2 activator has received clinical approval and several electrophilic modifiers of the cysteine-based sensor KEAP1 and inhibitors of its interaction with NRF2 are now in clinical development. However, challenges regarding target specificity, pharmacodynamic properties, efficacy and safety remain.Entities:
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Year: 2019 PMID： 30610225 DOI： 10.1038/s41573-018-0008-x
Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694