Mohamed Abdelmawla1, Deepak Louis2, Michael Narvey2, Yasser Elsayed2. 1. Department of Pediatrics, King Fahd Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. 2. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Abstract
OBJECTIVE: To test the hypothesis that a lung ultrasound severity score (LUSsc) can predict the development of chronic lung disease (CLD) in preterm neonates. STUDY DESIGN: Preterm infants <30 weeks' gestational age were enrolled in this study. Lung ultrasound (LUS) was performed between 1 and 9 postnatal weeks. All ultrasound studies were done assessing three lung zones on each lung. Each zone was given a score between 0 and 3. A receiver operating characteristic curve was constructed to assess the ability of LUSsc to predict CLD. RESULTS: We studied 27 infants at a median (interquartile range [IQR]) gestational age and birth weight of 26 weeks (25-29) and 780 g (530-1,045), respectively. Median (IQR) postnatal age at the time of LUS studies was 5 (2-8) weeks. Fourteen infants who developed CLD underwent 34 studies. Thirteen infants without CLD underwent 30 studies. Those who developed CLD had a higher LUSsc than those who did not (median [IQR] of scores: 9 [6-12] vs. 3 [1-4], p < 0.0001). An LUSsc cutoff of 6 has a sensitivity and specificity of 76 and 97% and positive and negative predictive values of 95 and 82%, respectively. Adding gestational age < 27 weeks improved sensitivity and specificity to 86 and 98% and positive and negative predictive values to 97 and 88%. CONCLUSION: LUSsc between 2 and 8 weeks can predict development of CLD in preterm neonates. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To test the hypothesis that a lung ultrasound severity score (LUSsc) can predict the development of chronic lung disease (CLD) in preterm neonates. STUDY DESIGN: Preterm infants <30 weeks' gestational age were enrolled in this study. Lung ultrasound (LUS) was performed between 1 and 9 postnatal weeks. All ultrasound studies were done assessing three lung zones on each lung. Each zone was given a score between 0 and 3. A receiver operating characteristic curve was constructed to assess the ability of LUSsc to predict CLD. RESULTS: We studied 27 infants at a median (interquartile range [IQR]) gestational age and birth weight of 26 weeks (25-29) and 780 g (530-1,045), respectively. Median (IQR) postnatal age at the time of LUS studies was 5 (2-8) weeks. Fourteen infants who developed CLD underwent 34 studies. Thirteen infants without CLD underwent 30 studies. Those who developed CLD had a higher LUSsc than those who did not (median [IQR] of scores: 9 [6-12] vs. 3 [1-4], p < 0.0001). An LUSsc cutoff of 6 has a sensitivity and specificity of 76 and 97% and positive and negative predictive values of 95 and 82%, respectively. Adding gestational age < 27 weeks improved sensitivity and specificity to 86 and 98% and positive and negative predictive values to 97 and 88%. CONCLUSION:LUSsc between 2 and 8 weeks can predict development of CLD in preterm neonates. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Sara Bobillo-Perez; Clara Sorribes; Paula Gebellí; Nuria Lledó; Marta Castilla; Miquel Ramon; Javier Rodriguez-Fanjul Journal: Eur J Pediatr Date: 2021-02-13 Impact factor: 3.183
Authors: Fiorella Migliaro; Serena Salomè; Iuri Corsini; Daniele De Luca; Letizia Capasso; Diego Gragnaniello; Francesco Raimondi Journal: Early Hum Dev Date: 2020-09-10 Impact factor: 2.079