Metal coordination-functionalized Au-Ag bimetal SERS nanoprobe for sensitive detection of glutathione.

We demonstrated a surface-enhanced Raman spectroscopy (SERS) nanoprobe, neocuproine-Cu (Nc-CuII)-functionalized Au-Ag "nanobowls" (Au-Ag NBs/Nc-CuII), for detection of glutathione (GSH). Detection was accomplished with alternation of SERS spectra from Nc-CuII into Nc-CuI resulting from the reaction of GSH with Nc-CuII on Au-Ag NBs. This nanoprobe exhibited high selectivity and sensitivity (μM) towards GSH.