| Literature DB >> 30605614 |
Wuheng Dong1, Yao Yuan1, Xiaoshuang Gao1, Miladili Keranmu1, Wanfang Li1, Xiaomin Xie1, Zhaoguo Zhang1,2.
Abstract
A fac-Ir(ppy)3-catalyzed intermolecular dearomative cyclization of 2-bromo-2-((5-bromofuran-2-yl)methyl)malonate and alkynes affording substituted spirolactones in yields of 19-91% via a 5- exo-dig radical cyclization under visible light is presented. This method provides a new access to the synthesis of spirocycle skeletons applying water as an external oxygen source under mild reaction conditions.Entities:
Year: 2019 PMID： 30605614 DOI： 10.1021/acs.joc.8b02881
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354